Benutzerspezifische Werkzeuge

Experimentelle Dermatologie

Head of research

  Focus of research / Current projects

A novel role for nuclear caspase-8 in tumor progression

We have identified a novel molecular mechanism how nuclear caspase-8 generates a de facto loss of the tumor suppressor wildtype p53 in aggressive cancer cells, thereby promoting therapy resistance and tumor relapse.
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Death ligand TRAIL as an alternative treatment option for malignant melanoma

Exposure of tumor cells to sublethal drug doses may cause a phenotype switch from therapy responsive into highly proliferating metastatic and therapy resistant cancer cells. We investigate the role of focal adhesion kinase in inducing this phenotype switch in response to death receptor activation using second generation TRAIL receptor agonists with enhanced bioactivity.
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NETSKINMODELS: Engineering novel 3D skin models

By developing an organotypic full skin equivalent, harboring melanoma spheroids of we have invented a cell-based model that recapitulates both the 3-d organization and multicellular complexity of an organ/tumor in vivo but at the same time accommodates systematic experimental intervention.
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Interplay of caspase-8 and p53 in therapy resistance of malignant melanoma and head and neck cancer

TransCampus Initiative with Kings College London, Great Britain

In silico drug target prediction using metabolic modelling for the identification of repurposable drugs for melanoma

Joint authorship with the Université du Luxembourg

Strukturelle Veränderungen von p53 Mutationen und deren Konsequenzen

National cooperation with the Otto-von-Guericke University, Magdeburg, Germany

Team members (in alphabetic order)

Our research group frequently offers Master's theses on our main research areas. We are looking forward to your detailed application!


  • Office Prof. Dr. rer. nat. Dagmar Kulms: Universitätsklinikum Dresden, Fetscherstraße 74, 01307 Dresden - House 10, Room 0.215
  • Lab: NCT National Center of Tumor Diseases (NCT), Fetscherstraße 74, Haus 136, 01307 Dresden