Tracing oncogene-driven remodelling of the intestinal stem cell niche. Yum MK, Han S, Fink J, Wu SS, Dabrowska C, Trendafilova T, Mustata R, Chatzeli L, Azzarelli R, Pshenichnaya I, Lee E, England F, Kim JK, Stange DE, Philpott A, Lee JH, Koo BK, Simons BD. Nature. 2021 Jun;594(7863):442-447.
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. Smyth EC, Vlachogiannis G, Hedayat S, Harbery A, Hulkki-Wilson S, Salati M, Kouvelakis K, Fernandez-Mateos J, Cresswell GD, Fontana E, Seidlitz T, Peckitt C, Hahne JC, Lampis A, Begum R, Watkins D, Rao S, Starling N, Waddell T, Okines A, Crosby T, Mansoor W, Wadsley J, Middleton G, Fassan M, Wotherspoon A, Braconi C, Chau I, Vivanco I, Sottoriva A, Stange DE, Cunningham D, Valeri N. Gut. 2021 Sep;70(9):1632-1641.
Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. Dantes Z, Yen HY, Pfarr N, Winter C, Steiger K, Muckenhuber A, Hennig A, Lange S, Engleitner T, Öllinger R, Maresch R, Orben F, Heid I, Kaissis G, Shi K, Topping G, Stögbauer F, Wirth M, Peschke K, Papargyriou A, Rezaee-Oghazi M, Feldmann K, Schäfer AP, Ranjan R, Lubeseder-Martellato C, Stange DE, Welsch T, Martignoni M, Ceyhan GO, Friess H, Herner A, Liotta L, Treiber M, von Figura G, Abdelhafez M, Klare P, Schlag C, Algül H, Siveke J, Braren R, Weirich G, Weichert W, Saur D, Rad R, Schmid RM, Schneider G, Reichert M. JCI Insight. 2020 Aug 6;5(15):e137809.
Universal and Efficient Electroporation Protocol for Genetic Engineering of Gastrointestinal Organoids. Gaebler AM, Hennig A, Buczolich K, Weitz J, Welsch T, Stange DE, Pape K. J Vis Exp. 2020 Feb 18;(156).
Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE. Gastroenterology. 2019 Dec;157(6):1599-1614.e2.
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK. Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7.
CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids. Hennig A, Wolf L, Jahnke B, Polster H, Seidlitz T, Werner K, Aust DE, Hampe J, Distler M, Weitz J, Stange DE, Welsch T. Stem Cells Int. 2019 May 2;2019:1024614.
Human gastric cancer modelling using organoids. Seidlitz T, Merker SR, Rothe A, Zakrzewski F, von Neubeck C, Grützmann K, Sommer U, Schweitzer C, Schölch S, Uhlemann H, Gaebler AM, Werner K, Krause M, Baretton GB, Welsch T, Koo BK, Aust DE, Klink B, Weitz J, Stange DE. Gut. 2019 Feb;68(2):207-217.
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610-E619.
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H. Cell. 2013 Oct 10;155(2):357-68.
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H. Nature. 2012 Aug 30;488(7413):665-9.
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Science. 2012 Aug 10;337(6095):730-5.
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. Muñoz J*, Stange DE*, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H.EMBO J. 2012 Jun 12;31(14):3079-91.
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Wong VW*, Stange DE*, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Nat Cell Biol. 2012 Mar 4;14(4):401-8.
Controlled gene expression in primary Lgr5 organoid cultures. Koo BK*, Stange DE*, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H. Nat Methods. 2011 Dec 4;9(1):81-3.
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H. Gastroenterology. 2011 Nov;141(5):1762-72.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. Nature. 2011 Jul 4;476(7360):293-7.
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Nature. 2011 Jan 20;469(7330):415-8.
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Kosinski C, Stange DE, Xu C, Chan AS, Ho C, Yuen ST, Mifflin RC, Powell DW, Clevers H, Leung SY, Chen X. Gastroenterology. 2010 Sep;139(3):893-903.
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B. Gut. 2010 Sep;59(9):1236-44.
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H. Science. 2010 Mar 12;327(5971):1385-9.
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H. Cell Stem Cell. 2010 Jan 8;6(1):25-36.
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H. Gastroenterology. 2009 Oct;137(4):1333-45.e1-3.
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. Nature. 2009 May 14;459(7244):262-5.
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H. Gastroenterology. 2009 Jun;136(7):2187-2194.e1.
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. Cell. 2009 Mar 6;136(5):903-12.
High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter P. Clin Cancer Res. 2006 Jan 15;12(2):345-52.
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