Molekulare Mechanismen der Nukleinsäure-Erkennung
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Ausgewählte Publikationen
Mishra, H., Schlack-Leigers, C., Lim, E.L., Thieck, O., Magg, T., Raedler, J., Wolf, C., Klein, C., Ewers, H., Lee-Kirsch, M.A., Meierhofer, D., Hauck, F., Majer, O., 2024. Disrupted degradative sorting of TLR7 is associated with human lupus. Sci Immunol. 9, eadi9575. https://doi.org/10.1126/sciimmunol.adi9575
Wolf, C., Lim, E.L., Mokhtari, M., Kind, B., Odainic, A., Lara-Villacanas, E., Koss, S., Mages, S., Menzel, K., Engel, K., Dückers, G., Bernbeck, B., Schneider, D.T., Siepermann, K., Niehues, T., Goetzke, C.C., Durek, P., Minden, K., Dörner, T., Stittrich, A., Szelinski, F., Guerra, G.M., Massoud, M., Bieringer, M., De Oliveira Mann, C.C., Beltrán, E., Kallinich, T., Mashreghi, M.-F., Schmidt, S.V., Latz, E., Klughammer, J., Majer, O., Lee-Kirsch, M.A., 2024. UNC93B1 variants underlie TLR7-dependent autoimmunity. Sci Immunol. 9, eadi9769. https://doi.org/10.1126/sciimmunol.adi9769
Günther, C., Wolf, C., Fennen, L., Rösing, S., Beissert, S., Aringer, M., Lee-Kirsch, M.A., 2023. Case Report: Response of cutaneous lupus lesions in SLE to interferon receptor blockade parallels reduction of interferon score in blood. Front Immunol. 14, 1253279. https://doi.org/10.3389/fimmu.2023.1253279, open access
Wolf, C., Fischer, H., Kühl, J.-S., Koss, S., Jamra, R.A., Starke, S., Schultz, J., Ehl, S., Neumann, K., Schuetz, C., Huber, R., Hornung, V., Lee-Kirsch, M.A., 2023. Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9. J Allergy Clin Immunol. 152, 1336-1344.e5. https://doi.org/10.1016/j.jaci.2023.07.013, open access
Berndt, N., Wolf, C., Fischer, K., Cura Costa, E., Knuschke, P., Zimmermann, N., Schmidt, F., Merkel, M., Chara, O., Lee-Kirsch, M.A., Günther, C., 2022. Photosensitivity and cGAS-dependent IFN-1 activation in patients with lupus and TREX1 deficiency. J Invest Dermatol. 142, 633-640.e6. https://doi.org/10.1016/ j.jid.2021.04.037, open access
Wolf, C., Brück, N., Koss, S., Griep, C., Kirschfink, M., Palm-Beden, K., Fang, M., Röber, N., Winkler, S., Berner, R., Latz, E., Günther, C., Lee-Kirsch, M.A., 2020. Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol. 146, 1439-1442.e5. https://doi.org/10.1016/j.jaci.2020.04.002, open access
Zimmermann, N., Wolf, C., Schwenke, R., Lüth, A., Schmidt, F., Engel, K., Lee-Kirsch, M.A., Günther, C., 2019. Assessment of clinical response to Janus kinase inhibition in patients with familial chilblain lupus and TREX1 mutation. JAMA Dermatol. 155, 342. https://doi.org/10.1001/jamadermatol.2018.5077, open access
König, N., Fiehn, C., Wolf, C., Schuster, M., Cura Costa, E., Tüngler, V., Alvarez, H.A., Chara, O., Engel, K., Goldbach-Mansky, R., Günther, C., Lee-Kirsch, M.A., 2017. Familial chilblain lupus due to a gain-of-function mutation in STING. Ann Rheum Dis. 76, 468–472. https://doi.org/10.1136/annrheumdis-2016-209841
Wolf, C., Rapp, A., Berndt, N., Staroske, W., Schuster, M., Dobrick-Mattheuer, M., Kretschmer, S., König, N., Kurth, T., Wieczorek, D., Kast, K., Cardoso, M.C., Günther, C., Lee-Kirsch, M.A., 2016. RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat Commun. 7, 11752. https://doi.org/10.1038/ncomms11752, open access
Kretschmer, S., Wolf, C., König, N., Staroske, W., Guck, J., Häusler, M., Luksch, H., Nguyen, L.A., Kim, B., Alexopoulou, D., Dahl, A., Rapp, A., Cardoso, M.C., Shevchenko, A., Lee-Kirsch, M.A., 2015. SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis. 74, e17. https://doi.org/10.1136/annrheumdis-2013-204845, open access