Benutzerspezifische Werkzeuge

Leitung Klinische Forschung

Leiter

Prof. Dr. med. Angela Rösen-Wolff Prof. Dr. med. Angela Rösen-Wolff

Technische Leitung:

Stephan Heyden

Wissenschaftliche Mitarbeiter:
Frau Dr. rer. medic. Hella Luksch
Herr Dr. med. Stefan Winkler
Herr Dipl. Biol. Sören Reinke (Doktorand)
Frau MSc Mary Linge (Doktorandin)
Frau cand. med. Hannah Siedel (Doktorandin, EKPK Stipendiantin)
Herr cand. med. Paul Gelhardt (Doktorand)

Technische Assistenten:
Frau Katrin Höhne (MTA)
Frau Susanne Russ (MTA)

Forschungsprojekte (inkl. Drittmittel):

  • Inflammasom-assoziierte Defekte der zytoplasmatischen DAMP-Erkennung – Einfluss von Mutationen im CASP1-Gen auf Transkrption, Zytokunfreisetzung und Pyroptose ( DFG Klinische Forschergruppe 249 )
  • Verbundprojekt: Deutsches Netzwerk für Primäre Immundefekte (PID-NET): Teilprojekt A4 – Autoinflammatorische Erkrankungen (BMBF)
  • Etablierung eines neuen Ansatzes „in situ Tissue Engineering“ für die Knochendefektheilung ( DFG Transregio 79 )
  • Uncontrolled type 1 interferon responses in pediatric autoinflammatory with vascular inflammation, TRR237 "Nucleic acid immunity"

Ausgewählte Publikationen:

Grinstein L, Endter K, Hedrich CM, Reinke S, Luksch H, Schulze F, Robertson AAB, Cooper MA, Rösen-Wolff A, Winkler S (2018). An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. Clin Immunol 191:100-109

Schulze F, Malhan D, El Khassawna T, Heiss C, Seckinger A, Hose D, Rösen-Wolff A (2017). A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model. BMC Genomics 18(1):975.

Gabrielyan A, Neumann E, Gelinsky M, Rösen-Wolff A (2017). Metabolically-Conditioned Media Derived from Bone Marrow Stroma Cells or Human Skin Fibroblasts act as Effective Chemoattractants for Mesenchymal Stem Cells. Stem Cell Res Ther 8(1):212.

Stein R, Kapplusch F, Heymann MC, Russ S, Staroske W, Hedrich CM, Rösen-Wolff A, Hofmann SR (2016). Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division. J Biol Chem. 2016 Aug 26;291(35):18419-29.

Winkler S and Rösen-Wolff A (2015). Caspase-1: An integral regulator of innate immunity. Semin Immunopathol 37(4): 419-27.

Hofmann SR, Kubasch AS, Ioannidis C, Rösen-Wolff A, Girschick HJ, Morbach H, Hedrich CM (2015). Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release. Clin Immunol 161:300-7.

Heymann MC, Winkler S, Luksch H, Flecks S, Franke M, Ruß S, Özen S, Yilmaz E, Klein C, Kallinich T, Lindemann D, Brenner S, Ganser G, Roesler J, Rösen-Wolff A, Hofmann SR (2014). Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NFkB signaling. J Immunol 192(9):4379-85.

Luksch H, Romanowski MJ, Chara S, Tüngler V, Caffarena ER, Heymann M, Lohse P, Aksentijevich, Remmers EF, Flecks S, Quoos N, Gramatté J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rösen-Wolff A (2013). Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β (IL-1β). Hum Mut 34(1): 122-31.

Winkler S, Heyman MC, Franke M, Martin A, Roesler J, Rösen-Wolff A (2012). A Protective Role for Inflammasome Activation Following Injury. SHOCK, Vol. 37 (6):659.

Groessl, M, Luksch H, Rösen-Wolff A, Shevchenko A, Gentzel M (2012): Profiling of the human monocyte secretome by quantitative label-free mass spectrometry identifies stimulus–specific cytokines and inflammation-related proteins. J Proteomics 12: 2833-42.

Seckinger A, Meißner T, Moreaux J, Witte D, Hillengas J, Hose K, Reme T, Rösen-Wolff A, Jauch A, Schnettler R, Ewerbeck V, Goldschmidt H, Klein B, Hose D (2012). Clinical and prognostic role of Annexin A2 in multiple Myeoloma. Blood 120: 1087-94.

Hedrich CM, Bruck N, Paul D, Hahn G, Gahr M, Rösen-Wolff A."Mutation negative" familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies. Rheumatol Int. 2012 Sep;32(9):2629-36. doi: 10.1007/s00296-011-2019-3. Epub 2011 Jul 22.

Gentsch M, Kaczmarczyk A, van Leeuwen K, de Boer M, Kaus-Drobek M, Dagher MC, Kaiser P, Arkwright PD, Gahr M, Rösen-Wolff A, Bochtler M, Secord E, Britto-Williams P, Saifi GM, Maddalena A, Dbaibo G, Bustamante J, Casanova JL, Roos D, Roesler J. Hum Mutat. Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD). 2010 Feb;31(2):151-8.

Thieme S, Ryser M, Gentsch M, Brenner S, Stiehler M, Rölfing J, Gelinsky M, Rösen-Wolff A (2009). Stromal derived factor-1alpha directed chemoattraction of transiently CXCR4 overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds. Tissue Eng Part C 15 : 687-696.

Domaschke H, Gelinsky M, Burmeister B, Reinstorf A, Fleig R, Hanke T, Pompe W, Rösen-Wolff A (2006) In vitro ossification and remodelling of mineralized collagen I scaffolds. Tissue Eng 12:949-58.