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Prof. Dr. med. Jochen Hampe - Ausgewählte Originalarbeiten

Hampe J, Cuthbert A, Croucher PJP, Mirza MM, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson AJS, … Lewis C, Schreiber S, Mathew CG. An insertion mutation in the NOD2 gene predisposes to Crohn’s Disease in the German and British populations. Lancet 2001; 357: 1925-1928

Hampe J, Grebe J, Nikolaus S, Solberg C, Croucher PJP, Mascheretti S, Jahnsen J, Moum B, Klump B, Krawczak M, Mirza MM, Fölsch UR, Vatn M, Schreiber S. NOD2 genotype and clinical course of Crohn’s disease. Lancet 2002: 359; 1661-1665

Hampe J, Franke F, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Häsler R, Sipos B, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. A genome-wide association scan of non-synonymous SNPs identifies a susceptibility variant for Crohn disease in the autophagy-related 16-like (ATG16L1) gene. Nature Genetics, 2007; 39(2):207-211

Buch S, Schafmayer C, Völzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bäßmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Höll C, Seeger M, ElSharawy A, Fändrich F, Fölsch UR, Krawczak M, Schreiber S, Nürnberg P, Tepel J, Hampe J. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG5/ABCG8 as a susceptibility factor for human gallstone disease. Nature Genetics 2007; 39(8):995-9

Houlston RS, Webb E, ... Hampe J, Buch S, Schafmayer C, … Dunlop MG. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nature Genetics 2008 Dec;40(12):1426-35

Buch S, Schafmayer C, Völzke H, Seeger M, Miquel JF, Sookoian S, Egberts JH, Arlt A, Pirola CJ, Lerch MM, John U, Franke A, von Kampen O, Brosch M, Nothnagel M, Kratzer W, Boehm BO, Bröring CD, Schreiber S, Krawczak M, Hampe J. Evaluation of genome-wide loci of serum bilirubin levels as predictors of gallstone composition and gallstone risk. Gastroenterology 2010; 138(3):1102-11

Stickel F, Buch S, Lau K, .. Müller S, Seitz HK, Soyka M, Lerch MM, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians. Hepatology 2011;53:86-95

Brosch M, Ahrens M, Nothnagel M, Krawczak M, Laudes M, Sipos B, Becker T, Schreiber S, Röcken C, Schafmayer C, Hampe J. SFRS10-A Splicing Factor Gene Reduced in Human Obesity? Brosch M, von Schönfels W, Cell Metabolism 2012;15(3):265-6.

von Kampen O, Buch S, Nothnagel M, …. Miquel JF, Schafmayer C, Hampe J. Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus. Hepatology 2012;57(6):2407-17.

Ahrens M, Ammerpohl O, von Schönfels W, … Röcken C, Siebert R, Schafmayer C, Hampe J. DNA methylation analysis in nonalcoholic Fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metabolism 2013;18(2):296-302

Stickel F, Buch S, Zoller H, .. Datz C, Hampe J. Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis. Human Molecular Genetics 2014. 23(14):3883-90

Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schönfels W, Ahrens M, Heits N, Bell JT, Tsai PC, Spector TD, Deloukas P, Siebert R, Sipos B, Becker T, Röcken C, Schafmayer C, Hampe J. Obesity accelerates epigenetic aging of human liver. PNAS, 2014;111(43):15538-43

Buch S, Stickel S, Trépo E, … Moreno C, FranchimontD , Morgan MY, Hampe J. A two-stage genome-wide association study identifies TM6SF2 and MBOAT7 as novel risk loci for alcohol-relatived liver cirrhosis. Nature Genetics 2015, epub.