Offene Studien fortgeschritten

Name	Titel
AMALEE / CLEE011A2207	A phase II, multicenter, randomized, open-label study to evaluate the safety and efficacy of 400 mg of ribociclib in combination with non-steroidal aromatase inhibitors for the treatment of pre- and postmenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer who received no prior therapy for advanced disease
BYLIEVE	A phase II multicenter, open-label, two-cohort, noncomparative study to assess the efficacy and safety of alpelisib plus fulvestrant or letrozole in patients with PIK3CA mutant hormone receptor (HR) positive, HER2- negative advanced breast cancer (aBC), who have progressed on or after CDK 4/6 inhibitor treatment
Detect III	Eine Multizentrische, prospektiv randomisierte Phase III Studie zum Vergleich einer antineoplastischen Therapie allein versus einer antineoplastischen Therapie plus Lapatinib bei Patientinnen mit initial HER2-neg. metastasiertem Brustkrebs und HER“-pos. zirkulierenden Tumorzellen
Detect IV	Multizentrische, prospektive einarmige Phase II Studie zur Evaluation der Effektivität von Everolismus mit einer endokrinen Standardtherapie bei Patientinnen mit hormonrezeptorpositiven, Her2-neg.metastasiertem Brustkrebs und Her2 neg. zirkulierende Tumorzellen
Detect V	A multicenter, randomized phase III study to compare chemo- versus endocrine therapy in combination with dual HER2-targeted therapy of Herceptin® (trastuzumab) and Pertuzumab in patients with HER2 positive and hormone-receptor positive metastatic breast cancer.
DESIREE	A multicenter, randomized, double-blind, phase II study to evaluate the tolerability of an induction dose escalation of everolimus in patients with metastatic breast cancer
KeyLink-009	Open-label, Randomized, Phase 2/3 Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction of Clinical Benefit With First-line Chemotherapy Plus Pembrolizumab in Participants With Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer (TNBC) (KEYLYNK-009).
KeyNote-587	A Multicenter, Open label, Phase III Extension Trial to Study the Long-term Safety and Efficacy in Participants with Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab Trial.
NATALEE	A phase III, multicenter, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, early breast cancer
Nutrition	Prospektive, randomisierte, monozentrische Studie zum Einfluss einer intensiven Ernährungsberatung auf die Lebensqualität bei Patienten mit metastasiertem Brustkrebs unter CDK4/6- oder mTOR-Inhibition
Palmira	International, multicenter, randomized, open-label, phase II clinical trial to evaluate the efficacy and safety of continuation of palbociclib in combination with second-line endocrine therapy in Hormone Receptor-positive/HER2-negative advanced breast cancer patients who have achieved clinical benefit during first-line palbociclib-based treatment.
PRAEGNANT	Prospektives akademisches translationales Forschungsnetzwerk zur Optimierung der onkologischen Versorgungsqualität in der adjuvanten und fortgeschrittenen/ metastasierten Situation (Registerstudie)
Violette	Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination with Olaparib versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast Cancer Patients Stratified by Alterations in Homologous Recombinant Repair (HRR)-related Genes (including BRCA1/2)