Benutzerspezifische Werkzeuge

Project 3

Epigenetic modification in both innate and adaptive immune cells after severe infections in the lung and their extended effect on other non-communicable diseases like allergic diseases.

We would like to implement our research experience to investigate the deep epigenetic phenotyping of different cell types both innate and adaptive immunity in lung pre, during and post severe infections. For that matter, we intend to employ DNA methylation (whole genome methylation and pyrosequencing) as well as Histone modification techniques to understand how the cells are affected over time. Moreover, we would be investigating; how microbial peptides and metabolites work on changing the phenotype of a cell and extend these studies on lung cancer