Benutzerspezifische Werkzeuge

Project 2

The cross talk between innate and adaptive immune response (Immune training).

Here we are investigating further, how the innate immune response initiate the activation of the adaptive immune cells and develop the right immune response and how a strong viral infection like H1N1 infection can cause a drastic shift into the cross-talk and lead to loss of immune tolerance and an explosion of cytokine storm in the most severe cases, like the ones we see in SARS-COV-2 infections as well. I will be investigating how M1/M2 macrophages and N1/N2 neutrophils interact with regulatory T-cells and how the promotion of immune tolerance happens.