Benutzerspezifische Werkzeuge

Dr. med. Maik Stiehler, Ph.D.

maik_stiehler.jpgFacharzt für Orthopädie und Unfallchirurgie
Bereichsleiter regenerative Knochenforschung
Lehrbeauftragter Orthopädie
Leiter Knochenbank
Leiter deutsch-chinesische DAAD-Juniorwissenschaftlergruppe „Moderne Anwendungen der Biotechnologie“
Zusatzbezeichnung Manuelle Medizin, Sportmedizin

Forschungsschwerpunkt:

zellbasierte Knochenregeneration

Klinischer Schwerpunkt:

Hüftchirurgie, Endoprothetik

1995-2002   

Medizinstudium in Göttingen, Bern und Boston

2002-2010   

Facharztausbildung in Universitätskliniken Aarhus, Dänemark und Dresden


Ausgewählte Publikationen

Erst-/Letztautor-Originalarbeiten (Impact Faktor Summe = 53,31)

1.    Rauh J, Jacobi A, Stiehler M. Identification of stable reference genes for gene expression analysis of three-dimensional cultivated human bone marrow-derived mesenchymal stromal cells for bone tissue engineering. Tissue Engineering Part C (Impact Factor 4,065) 2014.
2.    Tang Y, Jacobi A, Vater C, Zou X and Stiehler M. Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. Biochem Pharmacol (Impact Factor 4,576) 2014.
3.    Rauh J, Despang F, Baas J, Liebers C, Pruss A, Gelinsky M, Gunther KP and Stiehler M. Comparative biomechanical and microstructural analysis of native versus peracetic acid-ethanol treated cancellous bone graft. Biomed Res Int (Impact Factor 2,880): 1-11, 2014.
4.    Tang Y, Vater C, Jacobi A, Liebers C, Zou X and Stiehler M. Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways. Br J Pharmacol (Impact Factor 5,067) 171: 2440-2456, 2014.
5.    Schmidt CP, Zwingenberger S, Walther A, Reuter U, Kasten P, Seifert J, Gunther KP and Stiehler M. Prevalence of Low Back Pain in Adolescent Athletes - an Epidemiological Investigation. Int J Sports Med (Impact Factor 2,268) 2014.
6.    Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Maetzig T, Goodman SB and Stiehler M. Enhancement of BMP-2 induced bone regeneration by SDF-1alpha mediated stem cell recruitment. Tissue Eng Part A (Impact Factor 4,065) 20: 810-818, 2014.
7.    Schildberg T, Rauh J, Bretschneider H and Stiehler M. Identification of suitable reference genes in bone marrow stromal cells from osteoarthritic donors. Stem Cell Res (Impact Factor 4,467) 11: 1288-1298, 2013.
8.    Stiehler C, Bünger C, Overall RW, Royer L, Schroeder M, Foss M, Besenbacher F, Kruhoffer M, Kassem M, Günther KP, Stiehler M. Whole-genome expression analysis of human mesenchymal stromal cells exposed to ultrasmooth tantalum versus titanium oxide surfaces. Cell Mol Bioeng (Impact Factor 1,443) 6: 199-209, 2013.
9.    Bernstein P, Kirschner S and Stiehler M. [Academic clinical medicine in orthopedic and trauma surgery: which route will the next generation choose?]. Unfallchirurg (Impact Factor 0,640) 116: 563-569, 2013.
10.    Jacobi A, Rauh J, Bernstein P, Liebers C, Zou X and Stiehler M. Comparative analysis of reference gene stability in human mesenchymal stromal cells during osteogenic differentiation. Biotechnol Prog (Impact Factor 1,853) 29: 1034-42, 2013.
11.    Stiehler M, Goronzy J, Hartmann A, Krummenauer F and Gunther KP. The First SICOT Oral Presentation Award 2011: imageless computer-assisted femoral component positioning in hip resurfacing: a prospective randomised trial. Int Orthop (Impact Factor 2,319) 37: 569-581, 2013.
12.    Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Matzig T, Gunther KP, Goodman SB and Stiehler M. Stem cell attraction via SDF-1alpha expressing fat tissue grafts. J Biomed Mater Res A (Impact Factor 2,834) 101: 2067-2074, 2013.
13.    Zwingenberger S, Niederlohmann E, Vater C, Rammelt S, Matthys R, Bernhardt R, Valladares RD, Goodman SB and Stiehler M. Establishment of a femoral critical-size bone defect model in immunodeficient mice. J Surg Res (Impact Factor 2,018) 181: e7-e14, 2013.
14.    Bernstein P, Sticht C, Jacobi A, Liebers C, Manthey S and Stiehler M. Expression pattern differences between osteoarthritic chondrocytes and mesenchymal stem cells during chondrogenic differentiation. Osteoarthritis Cartilage (Impact Factor 4,262) 18: 1596-1607, 2010.
15.    Stiehler M, Seib FP, Rauh J, Goedecke A, Werner C, Bornhauser M, Gunther KP and Bernstein P. Cancellous bone allograft seeded with human mesenchymal stromal cells: a potential good manufacturing practice-grade tool for the regeneration of bone defects. Cytotherapy (Impact Factor 3,055) 12: 658-668, 2010.
16.    Stiehler M, Bunger C, Baatrup A, Lind M, Kassem M and Mygind T. Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A (Impact Factor 2,834) 89: 96-107, 2009.
17.    Stiehler M, Lind M, Mygind T, Baatrup A, Dolatshahi-Pirouz A, Li H, Foss M, Besenbacher F, Kassem M and Bunger C. Morphology, proliferation, and osteogenic differentiation of mesenchymal stem cells cultured on titanium, tantalum, and chromium surfaces. J Biomed Mater Res A (Impact Factor 2,834) 86: 448-458, 2008.
18.    Stiehler M, Duch M, Mygind T, Li H, Ulrich-Vinther M, Modin C, Baatrup A, Lind M, Pedersen FS and Bunger CE . Optimizing viral and non-viral gene transfer methods for genetic modification of porcine mesenchymal stem cells. Adv Exp Med Biol (Impact Factor 1,825) 585: 31-48, 2006.

Koautor-Originalarbeiten (Impact Factor Summe = 44,982)
19.    Wobus M, List C, Dittrich T, Dhawan A, Duryagina R, Arabanian LS, Kast K, Wimberger P, Stiehler M, Hofbauer LC, Jakob F, Ehninger G, Anastassiadis K and Bornhauser M. Breast carcinoma cells modulate the chemoattractive activity of human bone marrow-derived mesenchymal stromal cells by interfering with CXCL12. Int J Cancer (Impact Factor 6,198) 2014.
20.    Bernstein P, Beuthien-Baumann B, Kotzerke J, Hofheinz F, Zessin J, Stiehler M and Gunther KP. Periacetabular bone metabolism following hip revision surgery. PET-based evaluation of allograft osteointegration. Nuklearmedizin (Impact Factor 1,322) 53: 2014.
21.    Zwingenberger S, Valladares RD, Walther A, Beck H, Stiehler M, Kirschner S, Engelhardt M and Kasten P. An epidemiological investigation of training and injury patterns in triathletes. J Sports Sci (Impact Factor 1,146) 32: 583-590, 2014.
22.    Rolfing JH, Baatrup A, Stiehler M, Jensen J, Lysdahl H and Bunger C. The osteogenic effect of erythropoietin on human mesenchymal stromal cells is dose-dependent and involves non-hematopoietic receptors and multiple intracellular signaling pathways. Stem Cell Rev (Impact Factor 4,523) 10: 69-78, 2014.
23.    Ferrer RA, Wobus M, List C, Wehner R, Schonefeldt C, Brocard B, Mohr B, Rauner M, Schmitz M, Stiehler M, Ehninger G, Hofbauer LC, Bornhauser M and Platzbecker U. Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide. Haematologica (Impact Factor 5,935) 98: 1677-1685, 2013.
24.    Rolfing JH, Bendtsen M, Jensen J, Stiehler M, Foldager CB, Hellfritzsch MB and Bunger C. Erythropoietin augments bone formation in a rabbit posterolateral spinal fusion model. J Orthop Res (Impact Factor 2,875) 30: 1083-1088, 2012.
25.    Goronzy J, Stiehler M, Kirschner S and Gunther KP. [Durom hip resurfacing. Short- to midterm clinical and radiological outcome]. Orthopade (Impact Factor 0,506) 39: 842-852, 2010.
26.    Bernstein P, Stiehler M and Haasper C. [Survey of the simultaneous management of clinical and research burdens in German University orthopaedic and trauma departments]. Z Orthop Unfall (Impact Factor 0,652) 148: 155-162, 2010.
27.    Thieme S, Ryser M, Gentsch M, Navratiel K, Brenner S, Stiehler M, Rolfing J, Gelinsky M and Rosen-Wolff A. Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds. Tissue Eng Part C Methods (Impact Factor 4,065) 15: 687-696, 2009.
28.    Mygind T, Stiehler M, Baatrup A, Li H, Zou X, Flyvbjerg A, Kassem M and Bunger C. Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds.  Biomaterials (Impact Factor 7,604) 28: 1036-1047, 2007.
29.    Hertel R, Hempfing A, Stiehler M and Leunig M. Predictors of humeral head ischemia after intracapsular fracture of the proximal humerus. J Shoulder Elbow Surg (Impact Factor 2,319) 13: 427-433, 2004.
30.    Behr TM, Behe M, Angerstein C, Gratz S, Mach R, Hagemann L, Jenner N, Stiehler M, Frank-Raue K, Raue F and Becker W. Cholecystokinin-B/gastrin receptor binding peptides: preclinical development and evaluation of their diagnostic and therapeutic potential. Clin Cancer Res (Impact Factor 7,837) 5: 3124s-3138s, 1999.

Übersichtsarbeiten
31.    Stiehler M, Zobel F, Hannemann F, Schmitt J, Lutzner J, Kirschner S, Gunther KP and Hartmann A. [Complications of metal-on-metal tribological pairing]. Orthopade 43: 79-91, 2014.
32.    Gunther KP, Lutzner J, Hannemann F, Schmitt J, Kirschner S, Goronzy J, Stiehler M, Lohmann C and Hartmann A . [Update on metal-on-metal hip joints]. Orthopade 42: 373-387, 2013.
33.    Zwingenberger S, Nich C, Valladares RD, Yao Z, Stiehler M and Goodman SB. Recommendations and considerations for the use of biologics in orthopedic surgery. BioDrugs 26: 245-256, 2012.
34.    Rauh J, Milan F, Gunther KP and Stiehler M. Bioreactor systems for bone tissue engineering. Tissue Eng Part B Rev 17: 263-280, 2011.
35.    Vater C, Kasten P and Stiehler M. Culture media for the differentiation of mesenchymal stromal cells. Acta Biomater 7: 463-477, 2011.
36.    Bernstein P, Bornhauser M, Gunther KP and Stiehler M. [Bone tissue engineering in clinical application: assessment of the current situation]. Orthopade 38: 1029-1037, 2009.
37.    Gunther KP, Witzleb WC, Stiehler M and Kirschner S. [Revision surgery of hip resurfacing]. Orthopade 37: 685-694, 2008.

Buchkapitel

Stiehler M und Günther KP. Epidemiologie des Hüftengelenkersatzes. In: Claes, Kirschner, Perka, Rudert (Hrsg.): AE-Manual der Endoprothetik. Springer Berlin, 2011 (ISBN 978-3-642-14645-9).
Thielemann F, Günther KP, Stiehler M. Pathophysiologie der Adipositas – Orthopädische Aspekte bei Kindern und Erwachsenen. In: Lewandowski, Bein (Hrsg.): Adipositas-Management in Anästhesie, Chirurgie, Intensivmedizin und Notfallmedizin. Medizinisch Wissenschaftliche Verlagsgesellschaft Berlin, 2012 (ISBN 978-3-941468-50-4).

Stiehler M, Kirschner S, Günther KP. Resurfacing Arthroplasty of the Hip, European Surgical Orthopaedics and Traumatology: 2621-2634, 2014.

Günther KP, Kirschner S, Stiehler M, Hartmann A. Instability following total hip arthroplasty. European Surgical Orthopaedics and Traumatology: 2495-2510, 2014.

Patente

Stiehler M, Rauh J, Milan F: „Perfusionsbioreaktor zum Kultivieren von Zellen auf Gerüstmaterialien“ (EPA-Nr. 12706764.3-1501)