Benutzerspezifische Werkzeuge

Osseointegration of Titanium Prostheses on the Footplate"Osseointegration of a collagen II+chondroitin sulfate-coated titanium footplate anchor" picture from Marcus Neudert et al. (https://doi.org/10.1007/s10162-009-0202-y)

Osseointegration of Titanium Prostheses on the Footplate

Drill dust-induced osseointegration with the aim for rehabilitation of acquired and congenital hearing impairments

Aside from eliminating bone-destroying inflammation, the main therapy objective in treating chronic middle ear infections is rehabilitating hearing. Thus far, only poor postoperative hearing results have been achieved, after extensive inflammatory-induced destruction of the ossicular chain. This is due to a high rate of prosthesis dislocation. A stable and continuous anchor for the prosthesis in the middle ear could be achieved using the patient´s own drill dust.

The drill dust produced by reconstructive surgery can be introduced onto a suitable prosthetic footplate, which in turn is capable of controlled osseointegration by minimizing forces acting on it. During a second surgical intervention the coupling of the sound-conducting mechanism is realised through a prosthesis between the tympanic membrane and the previous, now firmly implanted, prosthetic footplate.

Therefore, the development of a suitable implant that can uptake bone dust, bonds well to the footplate and simultaneously stabilises the process of osseointegration is fundamental. The proposers previous research shows that growth factor-induced osseointegration of a titanium prosthesis onto the footplate can be achieved. The footplate in turn is extremely fragile, hence it holds only some cells that can be activated. Attaching active bone-producing cells together with the prosthesis to the footplate seems to be a much more promising approach to solving this problem.

 Funding

 

Publications:

  • Neudert, M., Beleites, T., Ney, M., Kluge, A., Lasurashvili, N., Bornitz, M., Scharnweber, D., & Zahnert, T. (2010). Osseointegration of Titanium Prostheses on the Stapes Footplate. J Assoc Res Otolaryngol, 11(2), 161–171. https://doi.org/10.1007/s10162-009-0202-y
  • Neudert, M., Berner, M., Bornitz, M., Beleites, T., Ney, M., & Zahnert, T. (2007). Osseointegration of prostheses on the stapes footplate: Evaluation of the biomechanical feasibility by using a finite element model. J Assoc Res Otolaryngol, 8(4), 411–421. https://doi.org/10.1007/s10162-007-0094-7