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Osseointegration of titanium prostheses on the footplate

Osseointegration of titanium prostheses on the footplate

Drill dust-induced osseointegration with the aim for rehabilitation of acquired and congenital hearing impairments

Aside from eliminating bone-destroying inflammation, the main therapy objective in treating chronic middle ear infections is rehabilitating hearing. Thus far, only poor postoperative hearing results have been achieved, after extensive inflammatory-induced destruction of the ossicular chain. This is due to a high rate of prosthesis dislocation. A stable and continuous anchor for the prosthesis in the middle ear could be achieved using the patient´s own drill dust.

The drill dust produced by reconstructive surgery can be introduced onto a suitable prosthetic footplate, which in turn is capable of controlled osseointegration by minimizing forces acting on it. During a second surgical intervention the coupling of the sound-conducting mechanism is realised through a prosthesis between the tympanic membrane and the previous, now firmly implanted, prosthetic footplate.

Therefore, the development of a suitable implant that can uptake bone dust, bonds well to the footplate and simultaneously stabilises the process of osseointegration is fundamental. The proposers previous research shows that growth factor-induced osseointegration of a titanium prosthesis onto the footplate can be achieved. The footplate in turn is extremely fragile, hence it holds only some cells that can be activated. Attaching active bone-producing cells together with the prosthesis to the footplate seems to be a much more promising approach to solving this problem.

Funded by Bundesministerium für Bildung und Forschung. FKZ: 01EZ1124A

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