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Development of Middle Ear ImplantsLeft: "Titanium Clip Prosthesis" picture from Karl-BerndImage et al. (; Right: "Flexible Ossicular Replacement Prosthesis" from Thomas Beleites et al. (

Development of Middle Ear Implants

The lab can reflect upon a long history of research on middle ear reconstruction. Various ossicular replacement prostheses have been tested and developed.  Flexible prostheses with an integrated microjoint are the current challenge in research (Flexible ossicular replacement prosthesis).

Advanced manufacturing technologies in 3D printing (like Electrospinning, Fused Deposition Modeling) allow for new methods/therapies in tympanic membrane reconstruction a highly topical field of research.

To achieve a stable and continuous anchor for the prosthesis in the middle ear osseointegration for titanium prostheses on the footplate were developed.


  • Stoppe, T., Bornitz, M., Lasurashvili, N., Sauer, K., Zahnert, T., Zaoui, K., Beleites, T., 2018. Function, Applicability, and Properties of a Novel Flexible Total Ossicular Replacement Prosthesis With a Silicone Coated Ball and Socket Joint. Otology & Neurotology 39, 739–747.
  • Stoppe, T., Bornitz, M., Lasurashvili, N., Sauer, K., Zahnert, T., Beleites, T., 2017. Middle ear reconstruction with a flexible prosthesis. Current Directions in Biomedical Engineering 3, 143–146.

  • Neudert, M., Bornitz, M., Lasurashvili, N., Schmidt, U., Beleites, T., Zahnert, T., 2016. Impact of Prosthesis Length on Tympanic Membrane’s and Annular Ligament’s Stiffness and the Resulting Middle Ear Sound Transmission. Otol Neurotol 37, e369–e376.
  • Arechvo, I., Bornitz, M., Lasurashvili, N., Zahnert, T., Beleites, T., 2012. New total ossicular replacement prostheses with a resilient joint: experimental data from human temporal bones. Otol Neurotol 33, 60–66.

  • Arechvo, I., Zahnert, T., Bornitz, M., Neudert, M., Lasurashvili, N., Simkunaite-Rizgeliene, R., Beleites, T., 2012. The ostrich middle ear for developing an ideal ossicular replacement prosthesis. Eur Arch Otorhinolaryngol 270, 37–44.

  • Beleites, T., Bornitz, M., Offergeld, C., Neudert, M., Hüttenbrink, K.-B., Zahnert, T., 2007. Experimental investigations on middle ear prostheses with an integrated micro joint. Laryngorhinootologie 86, 649–654.

  • Hüttenbrink, K.-B., Zahnert, T., Wüstenberg, E.G., Hofmann, G., 2004. Titanium clip prosthesis. Otol Neurotol 25, 436–442.