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Subproject 7
Pathogenetic mechanisms in autoimmunity induced by deregulated zytosolic nucleic-acid recognition
Subproject 6
Aicardi-Goutières Syndrom-associated gene products as potential sensors or antiviral effectors for exogenous viruses
Subproject 5
The role of defects in nucleic acid metabolism for the pathogenesis of cutaneous autoimmune diseases
Subproject 4
The role of the Trex1-, RNase H2- and SAMHD1-associated intracellular nucleic acid metabolism during restriction of retroelements - implications for the pathogenesis of systemic autoimmunity
Subproject 3
Mass spectrometric analysis of the caspase 1-associated secretome
Subproject 2
Mapping dynamic protein interactions of Receptor interacting protein 2 (RIP2), Pro-Caspase-1, ASC and other CARD-proteins using life-cell imaging
Subproject 1
Inflammasome-associated defects of cytoplasmatic DAMP recognition - Effects of CASP1 gene mutations on transcription, cytokine release patterns and pyroptosis
Subprojects
Clinical Research Unit 249 - Defects of the innate immune system in autoinflammation and autoimmunity
Clinical Research Group 249
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