Benutzerspezifische Werkzeuge

Forschungsbereich: Neurobiologie Psychiatrischer Störungen

Research statement

The comprehensive characterization of the neurobiology underlying psychiatric disorders remains challenging. Genetic risk variants in combination with environmental factors are thought to interfere with brain development and consequently manifest as deviations at different levels of neurobiological integrity. However, the mechanisms by which these systems interact in producing the delayed onset of disease- specific and comprehensive symptoms remain largely unknown. This is also reflected in limitations of available treatment strategies often associated with poor symptom alleviation, treatment resistance and side effects.

The section comprises the research group Neurobiology of Psychiatric Disorders (Nadine Bernhardt, PhD) and the associated research group Experimentelle Psychiatrie (Prof. Dr. Christine Winter, Dept. of Psychiatry and Psychotherapy, Charité University Medicine Berlin, , https://psychiatrie-psychotherapie.charite.de).

We use rodent models of psychopathology and neuromodulatory strategies to gain mechanistic insights into disease specific neuropathology and offer a platform to evaluate new treatment strategies, with a primary focus on preventive interventions. Within the clinical setting we additionally aim to combine basic research in humans with approaches in rodent models. We apply methods from various scientific fields such as behavior, molecular biology, biochemistry, immunology, magnetic resonance imaging (MRI), pharmacotherapy and electrophysiology.

Lab Members

Assistants

Sabine Einert
Kristin Wogan

Doctoral Researchers

Elizabeth Barroeta Hlusicka
Bettina Habelt
Alena Kozlova

MD-Candidates

Rebecca Winter
                        Kristin Lange
                             Alexandra Filla
                           Maike Lieser
                              Isabell Neubert
Fatih Ögel
Lena Zander
Maximilian Glienke
Miriam Pietsch
Vincent Herbers
Cindy Schwarz

Students

Fabian Stechbarth
Mirjam Zachow    

Selected Publications

Meyerolbersleben L, Winter C, Bernhardt N. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. accepted 16-Sep-2019 Behav Brain Res.

Bernadoni F*, Bernhardt N*, Pooseh S, King JA, Geisler D, Ritschel F, Boehm I, Seidel M, Roessner V, Smolka MN, Ehrlich S. Metabolic state and decision-making in acute and recovered female patients with anorexia nervosa accepted. 03-Sep-2019 J Psychiatr Neurosci

Bernhardt N, Obst E, Nebe S, Pooseh S, Wurst FM, Weinmann W, Smolka MN, Zimmermann US. Acute Alcohol Effects on Impulsive Choice – Meaningful Individual Differences during Adolescents. J Psychopharmacol. 2019, 33(3):316-325

Hadar R, Winter R, Henriette Edemann-Callesen H, Wieske F, Habelt B, Khadka N, Felgel V, Barroeta Hlusicke E, Reis J, Funke K, Fritsch B, Bernhardt N, Bikson M, Nitsche M, Winter C. Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats. Mol Psychiatry. 2019 Jan 28 doi: 10.1038/s41380-019-0356-x.

Bernhardt N, Lieser MK, Hlusicka E-B, Habelt B, Wieske F, Edemann-Callesen H, Garthe A, Winter C. Learning deficits in rats overexpressing the dopamine transporter. Sci Rep 2018, 8(1):14173.

Edemann-Callesen H, Habelt B, Wieske F, Jackson, Khadka N, Mattei, Bernhardt N, Heinz A, Liebetanz, Bikson M, Padberg, Hadar R, Nitsche N, Winter C. Non-invasive neuromodulation reduces repetitive behavior in a rat model through the sensorimotor striato-thalamo-cortical circuit. Transl Psychiatry. 2018, 8(1):11.

Pooseh S, Bernhardt N, Guevara A, Huys QJM, Smolka M; Value based decision making – An adaptive algorithm for binary choice presentation to quickly and reliably assess different facets of Impulsivity. Behav Res Methods. 2018, 50(1):236-249

Bernhardt N, Nebe S, Pooseh S, Sebold M, Sommer C, Birkenstock J, Zimmermann US, Heinz A, Smolka MN. Impulsive decision making in young adult social drinkers and detoxified alcohol-dependent patients: A cross-sectional and longitudinal study. Alcohol Clin Exp Res. 2017, 41(10):1794-1807.

Bernhardt N, Memic F, Gezelius H, Thiebes A-L, Vallstedt A and Kullander K. DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. Dev Biol. 2012, 366:279–289.