Benutzerspezifische Werkzeuge

Forschungsbereich: Neurobiologie Psychiatrischer Störungen

Research statement

The comprehensive characterization of the neurobiology underlying psychiatric disorders remains challenging. Genetic risk variants in combination with environmental factors are thought to interfere with brain development and consequently manifest as deviations at different levels of neurobiological integrity. However, the mechanisms by which these systems interact in producing the delayed onset of disease- specific and comprehensive symptoms remain largely unknown. This is also reflected in limitations of available treatment strategies often associated with poor symptom alleviation, treatment resistance and side effects.

The section comprises the research groups Neurobiology ( Nadine Bernhardt, PhD ) and Experimentelle Psychiatrie ( Prof. Dr. Christine Winter , Dept. of Psychiatry and Psychotherapy, Charité University Medicine Berlin, , https://psychiatrie-psychotherapie.charite.de).

Together we use rodent models of psychopathology and neuromodulatory strategies to gain mechanistic insights into disease specific neuropathology and offer a platform to evaluate new treatment strategies, with a primary focus on preventive interventions. Within the clinical setting we additionally aim to combine basic research in humans with approaches in rodent models. We apply methods from various scientific fields such as behavior, molecular biology, biochemistry, immunology, magnetic resonance imaging (MRI), pharmacotherapy and electrophysiology.

Lab Members

Assistants

Sabine Einert
Kristin Wogan
Bettina Habelt

Doctoral students

Elizabeth Barroeta Hlusicka
Rebecca Winter
Kristin Lange
Alexandra Filla
Maike Lieser
Isabell Neubert
Fatih Ögel

Master students

Meike Pelz
Esther Akinola
Benson Akinola
Lukas Meyerolbersleben
Mirjam Zachow

Alumni

Nadine Hornauer
Charlotte Kling
Yuliya Stukanova

Selected Publications

Bernhardt N, Lieser MK, Barroeta Hlusicka E, Habelt B, Wieske F, Edemann-Callesen H, Garthe A, Winter C. (2018) Learning deficits in rats overexpressing the dopamine transporter.  Scientific Reports

Edemann-Callesen H, Habelt B, Wieske F, Jackson M, Khadka N, Mattei D, Bernhardt N, Heinz A, Liebetanz D, Bikson M, Padberg F, Hadar R, Nitsche MA, Winter C (2018) Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit. Translational Psychiatry 8:11.

Bernhardt N, Nebe S , Pooseh S ,Sebold M, Sommer C, Birkenstock J, Zimmermann US, Heinz A, Smolka MN. (2017) Impulsive decision making in young adult social drinkers and detoxified alcohol-dependent patients: A cross-sectional and longitudinal study. Alcohol Clin Exp Res. doi: 10.1111/acer.13481.

Hadar, R., Bikovski, L., Soto-Montenegro, M.L., Schimke, J., Maier, P., Ewing, S., Voget, M., Wieske, F., Götz, T., Desco, M., et al. (2017). Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia. Mol. Psychiatry.

Pooseh, S., Bernhardt, N., Guevara, A., Huys, Q.J.M., and Smolka, M.N. (2017). Value-based decision-making battery: A Bayesian adaptive approach to assess impulsive and risky behavior. Behav Res Methods.

Nebe, S., Kroemer, N.B., Schad, D.J., Bernhardt, N., Sebold, M., Müller, D.K., Scholl, L., Kuitunen-Paul, S., Heinz, A., Rapp, M.A., et al. (2017). No association of goal-directed and habitual control with alcohol consumption in young adults. Addiction Biology

Hadar, R., Edemann-Callesen, H., Reinel, C., Wieske, F., Voget, M., Popova, E., Sohr, R., Avchalumov, Y., Priller, J., van Riesen, C., et al. (2016). Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders. Scientific Reports 6 .

Hadar, R., Dong, L., Del-Valle-Anton, L., Guneykaya, D., Voget, M., Edemann-Callesen, H., Schweibold, R., Djodari-Irani, A., Goetz, T., Ewing, S., et al. (2016). Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation. Brain Behav Immun.

Hadar, R., Vengeliene, V., Barroeta Hlusicke, E., Canals, S., Noori, H.R., Wieske, F., Rummel, J., Harnack, D., Heinz, A., Spanagel, R., et al. (2016). Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens. Transl Psychiatry 6 , e840.

Rummel, J., Voget, M., Hadar, R., Ewing, S., Sohr, R., Klein, J., Sartorius, A., Heinz, A., Mathé, A.A., Vollmayr, B., et al. (2016). Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression. Journal of Psychiatric Research 81 , 36–45.

Edemann-Callesen, H., Voget, M., Empl, L., Vogel, M., Wieske, F., Rummel, J., Heinz, A., Mathé, A.A., Hadar, R., and Winter, C. (2015). Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System. Brain Stimulation 8 , 714–723.

Garbusow, M., Schad, D.J., Sebold, M., Friedel, E., Bernhardt, N., Koch, S.P., Steinacher, B., Kathmann, N., Geurts, D.E.M., Sommer, C., et al. (2015). Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence: PIT and alcohol relapse. Addiction Biology

Hadar, R., Soto-Montenegro, M.L., Götz, T., Wieske, F., Sohr, R., Desco, M., Hamani, C., Weiner, I., Pascau, J., and Winter, C. (2015). Using a maternal immune stimulation model of schizophrenia to study behavioral and neurobiological alterations over the developmental course. Schizophrenia Research.

Winter, C., Bregman, T., Voget, M., Raymond, R., Hadar, R., Nobrega, J.N., and Hamani, C. (2015). Acute high frequency stimulation of the prefrontal cortex or nucleus accumbens does not increase hippocampal neurogenesis in rats. J Psychiatr Res 68 , 27–29.

Bernhardt, N.R., Memic, F., and Kullander, K. (2013). Genetic analysis of left-right coordination of locomotion. Frontiers in Bioscience (Landmark Edition) 18, 21.

Bernhardt, N., Memic, F., Gezelius, H., Thiebes, A.-L., Vallstedt, A., and Kullander, K. (2012). DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. Developmental Biology 366, 279–289.