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Alves Lab - Metabolic Regulation & Cell Function

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Ergebnis:

Lab Members

Dr. Alves, Tiago

Group leader

Ghosh, Soujanya

PhD student

Gronert, Anika

PhD student

Kesic, Bozena

Technician 

Professional Experience

  • Since 2020: Group Leader Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD)
  • Since 2018: Research Group Leader, Faculty of Medicine and University Hospital Carl Gustav Carus of Technische Universität Dresden (TUD), Germany
  • 2016–2018: Associate Research Scientist, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
  • 2013–2016: PostDoc, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
  • 2012–2013: PostDoc, Department of Anesthesiology and Bioengineering, University of Washington, Seattle, WA, USA
  • 2010–2012: PostDoc, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA

Selected Publications

  • Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG. Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health. Cell Metab. Nov 3;32(5):751-766.e11 (2020)
  • Lewandowski SL, Cardone RL, Foster HR, Ho T, Potapenko E, Poudel C, VanDeusen HR, Sdao SM, Alves TC, Zhao X, Capozzi ME, de Souza AH, Jahan I, Thomas CJ, Nunemaker CS, Davis DB, Campbell JE, Kibbey RG, Merrins MJ.Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway. Cell Metab.  Nov 3;32(5):736-750.e5 (2020)
  • Song JD, Alves TC, Befroy DE, Perry RJ, Mason GF, Zhang XM, Munk A, Zhang Y, Zhang D, Cline GW, Rothman DL, Petersen KF, Shulman GI. Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference. Cell Metab. Nov 3;32(5):726-735e5 (2020).  
  • Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA. Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis. Cell Rep.  May 12;31(6):107623 (2020): 
  • Jesinkey, S R, Madiraju, A K, Alves, T C, Yarborough, O H, Cardone, R L, Zhao, X, Parsaei, Y, Nasiri, A R, Butrico, G, Liu, X, Molina, A J, Rountree, A M, Neal, A S, Wolf, D M, Sterpka, J, Philbrick, W M, Sweet, I R, Shirihai, O H and Kibbey, R G. Mitochondrial GTP Links Nutrient Sensing to beta Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep 28: 759-772 e10 (2019)
  • Yu, P, Wilhelm, K, Dubrac, A, Tung, J K, Alves, T C, Fang, J S, Xie, Y, Zhu, J, Chen, Z, De Smet, F, Zhang, J, Jin, S W, Sun, L, Sun, H, Kibbey, R G, Hirschi, K K, Hay, N, Carmeliet, P, Chittenden, T W, Eichmann, A, Potente, M and Simons, M. FGF-dependent metabolic control of vascular development. Nature 545: 224-228 (2017)
  • Madiraju, A K, Alves, T, Zhao, X, Cline, G W, Zhang, D, Bhanot, S, Samuel, V T, Kibbey, R G and Shulman, G I. Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proc Natl Acad Sci U S A 113: E3423-30 (2016)
  • Alves, T C, Pongratz, R L, Zhao, X, Yarborough, O, Sereda, S, Shirihai, O, Cline, G W, Mason, G and Kibbey, R G. Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metab 22: 936-47 (2015)
  • Alves, T C, Befroy, D E, Kibbey, R G, Kahn, M, Codella, R, Carvalho, R A, Falk Petersen, K and Shulman, G I. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance. Hepatology 53: 1175-81 (2011)

Funding and Awards

 

Collaborations