Alexaki Lab - Neuroinflammation
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Lab Members
Professional Experience
- 2022: Habilitation “Endocrine and metabolic mechanisms regulating systemic and central inflammation” – Faculty of Medicine and University Hospital Carl Gustav Carus of Technische Universität Dresden (TUD), Germany
- Since 2016: Group leader, Institute of Clinical Chemistry and Laboratory Medicine, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
- 2013 - 2016: Junior group leader, Institute of Clinical Chemistry and Laboratory Medicine, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
- 2012 - 2013: Senior postdoc, Division for Vascular Inflammation, Diabetes and Kidney, Department of Internal Medicine III, Medical School, Technische Universität Dresden, Germany
- 2008 - 2011: Research fellow, Medical School, University of Crete, Greece
- 2006-2008: Postdoc, INSERM697, Paris, France
- 2002-2005: PhD, Medical School, University of Crete, Greece
Selected Publications
- Witt A, Mateska I, Palladini A, Sinha A, Wölk M, Harauma A, Bechmann N, Pamporaki C, Dahl A, Rothe M, Kopaliani Adolf C, Riester A, Wielockx B, Bornstein SR, Kroiss M, Peitzsch M, Moriguchi T, Fedorova M, Grzybek M, Chavakis T, MirtschinkP, Alexaki VI. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland. Sci Adv. 2023 Jul 21;9(29):eadf6710. doi: 10.1126/sciadv.adf6710
- Mateska I, Witt A, Hagag E, Sinha A, Yilmaz C, Thanou E, Sun N, Kolliniati O, Patschin M, Abdelmegeed H, Henneicke H, Kanczkowski W, Wielockx B, Tsatsanis C, Dahl A, Walch AK, Li KW, Peitzsch M, Chavakis T, Alexaki VI. Succinate mediates inflammation-induced adrenocortical dysfunction. Elife. 2023 Jul 14;12:e83064. doi: 10.7554/eLife.83064
- Chavakis T, Alexaki VI, Ferrante AW Jr. Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol. 2023 May;24(5):757-766. doi: 10.1038/s41590-023-01479-0.
Funding and Awards
 | EuroNeurotrophin - a European training network for the discovery of neurotrophins small molecule mimetics as potential therapeutic agents for neurodegeneration and neuroinflammation. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 765704 Main Supervisor ESR 8 (Evaluation of small molecule neurotrophin mimetics in models of neurodegeneration and neuroinflammation.) and Leader of WP4 (Scientific and Industrial Training Activities) |
| German Research Foundation (DFG): TRR 205: The Adrenal: Central Relay in Health and Disease - Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling (A07)
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Collaborations
Collaborator Name | Institute | Collaboration Theme |
Ünal Coskun Maria Fedorova Michal Grzybek | Center of Membrane Biochemistry and Lipid Research, University Clinic, Medical Faculty, TUD | Lipidomic analysis |
Panos Verginis | Medical Faculty, University of Crete | Neuroinflammation |
| Peter J Murray | MPI für Biochemie, Martinsried | Arginine metabolism Type 2 immunity |
| Jesse Williams | Dep. of Physiology, University of Minnesota | Adrenal gland |
| Matthias Blüher | Integrated Research and Treatment Centre (IFB), Adiposity Diseases, Leipzig University Medical Centre | Obesity, adipose tissue |