Benutzerspezifische Werkzeuge

Forschungsbereich: Neurobiologie Psychischer Störungen


Research statement

The comprehensive characterization of the neurobiology underlying psychiatric disorders remains challenging. Genetic risk variants in combination with environmental factors are thought to interfere with brain development and consequently manifest as deviations at different levels of neurobiological integrity. However, the mechanisms by which these systems interact in producing the delayed onset of disease- specific and comprehensive symptoms remain largely unknown. This is also reflected in limitations of available treatment strategies often associated with poor symptom alleviation, treatment resistance and side effects.

We use rodent models of psychopathology and neuromodulatory strategies to gain mechanistic insights into disease specific neuropathology and offer a platform to evaluate new treatment strategies, with a primary focus on preventive interventions. Within the clinical setting we additionally aim to combine basic research in humans with approaches in rodent models. We apply methods from various scientific fields such as behavior, molecular biology, biochemistry, immunology, magnetic resonance imaging (MRI), pharmacotherapy and electrophysiology.

The section comprises the following research groups:

Neurobiology of Psychiatric Disorders

MD Thesis available

We are looking for a highly motivated student that would like to perform a preclinical-experimental study informing the potential of preventive brain stimulation techniques for psychiatric disorders. For the success of the project, affinity to Matlab, Python and/or R is recommendable. The student will have the chance to participate in regular meetings with our partner Lab at King`s College London in addition to an on-site visit through the existing TransCampus network to obtain knowledge on state-of-the-art MRI data processing. The student will also learn how to perform multifaceted data analysis and manuscript preparation for a scientific publication. The samples for the study are already available. Thus, this study's experimental part and data analysis can be completed in 12 months with one free semester. Financial supported is available. The doctoral thesis can be written in English or German. If you are interested please contact:

Associated research group: Experimentelle Psychiatrie, Charité Berlin