Mirtschink Lab - Metabolic Control

Metabolic Control

Research Focus

Cellular stress, in response to inflammatory stimuli or tissue hypoxia leads to profound metabolic remodeling mediated by specific transcriptional and epigenetic determinants. On the other hand metabolic alterations themselves can reshape the transcriptome and epigenome of a cell. By using integrated transcriptomic, epigenomic, metabolomic and lipidomic approaches we aspire to decipher those intertwining mechanisms in order to improve the current understanding of common disease types and their molecular underpinnings.

Specific expertise

Cell metabolism
Cardio-metabolic disease
Gene regulatory cues
Integrated-omics

Lab Members

Dr. Mirtschink, Peter	Group leader	E-Mail
Dr. Staßburger, Katrin	Postdoc	E-Mail
Dr. Belavgeni, Alexia	Postdoc	E-Mail
Meyfarth, Paul	PhD Student	E-Mail
Choudhury Nath, Rajeshwari	PhD Student	E Mail
Bartko, Lisanne	MD-Student	E-Mail
Mirkin, Maria	MD-Student	E-Mail

Professional Experience

20XX

Selected Publications

Mirtschink, P, Bischof, C, Pham, M D, Sharma, R, Khadayate, S, Rossi, G, Fankhauser, N, Traub, S, Sossalla, S, Hagag, E, Berthonneche, C, Sarre, A, Stehr, S N, Grote, P, Pedrazzini, T, Dimmeler, S, Krek, W and Krishnan, J. Inhibition of the Hypoxia-Inducible Factor 1alpha-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease. Circulation 139: 2778-2792 (2019)
Mirtschink, P, Jang, C, Arany, Z and Krek, W. Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease. Eur Heart J 39: 2497-2505 (2018)
Mitroulis, I, Ruppova, K, Wang, B, Chen, L S, Grzybek, M, Grinenko, T, Eugster, A, Troullinaki, M, Palladini, A, Kourtzelis, I, Chatzigeorgiou, A, Schlitzer, A, Beyer, M, Joosten, L A B, Isermann, B, Lesche, M, Petzold, A, Simons, K, Henry, I, Dahl, A, Schultze, J L, Wielockx, B, Zamboni, N, Mirtschink, P, Coskun, U, Hajishengallis, G, Netea, M G and Chavakis, T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell 172: 147-161 e12 (2018)
Mirtschink, P, Krishnan, J, Grimm, F, Sarre, A, Horl, M, Kayikci, M, Fankhauser, N, Christinat, Y, Cortijo, C, Feehan, O, Vukolic, A, Sossalla, S, Stehr, S N, Ule, J, Zamboni, N, Pedrazzini, T and Krek, W. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature 522: 444-449 (2015)
Krishnan, J, Danzer, C, Simka, T, Ukropec, J, Walter, K M, Kumpf, S, Mirtschink, P, Ukropcova, B, Gasperikova, D, Pedrazzini, T and Krek, W. Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev 26: 259-70 (2012)

Funding and Awards

German Research Foundation (DFG):

2025: IRTG 3019 MEDIS-Metabolic and Endocrine Drivers of Infection Susceptibility: Regulation of adipogenesis and adipocyte fate by inflammatory signalling (Project number 522201563)
2024: Research Grant: ADAM10 sheddase-mediated myeloid bias after acute myocardial infarction (Project number 544115600)
2024: TRR 369: Defining the role of osteomorphs in inflammatory bone loss (Project number 501752319)
2024: TRR 369: Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging (Project number 501752319)

Collaborations

Collaborator Name	Institute	Collaboration Theme