Peitzsch and Traikov Lab - Experimental Mass Spectrometry Unit (EMS)

Dr. Mirko Peitzsch

• Since 2017: Head Experimental Mass Spectrometry, Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at TU Dresden, Dresden, Germany
• Since 2015: Staff Scientist, Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at TU Dresden, Dresden, Germany
• 2010 – 2015: Postdoctoral fellow, Institute of Clinical Chemistry and Laboratory Medicine, Clinical Neurochemistry group, University Hospital Carl Gustav Carus at TU Dresden, Dresden, Germany
• 2008 – 2010: Postdoctoral fellow, Medical Microbiology, Department of Laboratory Medicine, Microbial metabolomics and chemical marker analysis group, University of Lund, Sweden
• 2005 – 2008: PhD student, Johannes Gutenberg University of Mainz, Germany Establishment of analytical tools (GC/LC-ICP-MS) for elemental speciation analysis within the Interdisciplinary DFG research training program 826 "Trace analysis of elemental species: Method development and applications", (12/2008 Dr. rer. nat.)

Dr. Sofia Traikov

• Since 2023: Co-leader of Experimental Metabolomics, Institute of Clinical Chemistry and Laboratory Medicine, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
• 2020 - 2023: Senior postdoc and head of the Metabolomics Service in the research group of Dr. Jonathan Rodenfels at MPI-CBG Dresden, Germany
• 2015 - 2020: Postdoc at MPI-CBG Dresden, Germany
• 2010 - 2015. Postdoc at BIOTEC Dresden, Germany
• 2004 - 2009: PhD at the Hematology and Oncology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Dr. Mirko Peitzsch

• Langner M*, Fröbel D*, Helm J, Chavakis T, Peitzsch M^#, Bechmann N^#. Accurate redox state indication by in situ derivatization with N-ethylmaleimide - Profiling of transsulfuration and glutathione pathway metabolites by UPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Apr 1;1236:124062. *, ^# equal contribution
• Fröbel D, Stanke D, Langner M, Žygienė G, Bechmann N, Peitzsch M. Liquid chromatography-tandem mass spectrometry based simultaneous quantification of tryptophan, serotonin and kynurenine pathway metabolites in tissues and cell culture systems. J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Sep 1;1229:123870.
• Langner M, Mateska I, Bechmann N, Wielockx B, Chavakis T, Alexaki VI, Peitzsch M. Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices. J Chromatogr A. 2022 May 24;1671:463021. doi: 10.1016/j.chroma.2022.463021.
• Bechmann N, Watts D, Steenblock C, Wallace PW, Schürmann A, Bornstein SR, Wielockx B, Eisenhofer G, Peitzsch M. Adrenal hormone interactions and metabolism: A single sample multi-omics approach.Horm Metab Res 2021; May;53(5):326-334.
• Peitzsch M, Novos T, Kaden D, Kurlbaum M, van Herwaarden AE, Müller D, Adaway J, Grouzmann E, McWhinney B, Hoad K, Woolard G, Kema I, Boot C, Fassnacht M, Sweep F, Loh TP, Horvath AR, Eisenhofer G. Harmonization of LC-MS/MS measurements of plasma free normetanephrine, metanephrine and 3-methoxytyramine.Clin Chem 2021; Aug 5;67(8):1098-1112.
• Peitzsch M, Butch ER, Lovorn E, Mangelis A, Furman WL, Santana VM, Hero B, Berthold F, Shulkin BL, Huebner A, Eisenhofer G. Biochemical testing for neuroblastoma using plasma free 3-O-methyldopa, 3-methoxytyramine, and normetanephrine.Pediatr Blood Cancer 2020; 67(2):e28081
• Peitzsch M, Mangelis A, Eisenhofer G, Huebner A. Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: particular importance for early infancy.Clin Chim Acta 2019; 494:100-5
• Masjkur J, Gruber M, Peitzsch M, Kaden D, Di Dalmazi G, Bidlingmaier M, Zopp S, Langton K, Fazel J, Beuschlein F, Bornstein SR, Reincke M, Eisenhofer G. Plasma steroid profiles in subclinical compared with overt adrenal Cushing Syndrome.J Clin Endocrinol Metab 2019;104(10):4331-4340
• Eisenhofer G, Masjkur J, Peitzsch M, Di Dalmazi G, Bidlingmaier M, Gruber M, Fazel J, Osswald A, Beuschlein F, Reincke M. Plasma steroid metabolome profiling for diagnosis and subtyping patients with Cushing Syndrome.Clin Chem 2018;64(3):586-596
• Eisenhofer G, Peitzsch M, McWhinney BC. Impact of LC-MS/MS on the laboratory diagnosis of catecholamine-producing tumors.TRAC-Trends in Analytical Chemistry 2016; 84:106-115
• Eisenhofer G, Dekkers T, Peitzsch M, Dietz AS, Bidlingmaier M, Treitl M, Williams TA, Bornstein SR, Haase M, Rump LC, Willenberg HS, Beuschlein F, Deinum J, Lenders JWM, Reincke M. Mass spectrometry-based adrenal and peripheral venous steroid profiling for subtyping of primary aldosteronism.Clin Chem 2016;62(3):514-524
• Williams TA, Peitzsch M, Dietz AS, Dekkers T, Bidlingmaier M, Riester A, Treitl M, Rhayem Y, Beuschlein F, Lenders JW, Deinum J, Eisenhofer G, Reincke M. Genotype-specific steroid profiles associated with aldosterone-producing adenomas.Hypertension 2016; 67(1): 139-45
• Peitzsch M, Adaway JE, Eisenhofer G. Interference from 3-O-methyldopa with ultra-high performance LC-MS/MS measurements of plasma metanephrines: Chromatographic separation remains important. Clin Chem 2015; 61(7): 993-6
• Peitzsch M, Dekkers T, Haase M, Sweep FC, Quack I, Antoch G, Siegert G, Lenders JW, Deinum J, Willenberg HS, Eisenhofer G. An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.J Steroi Biochem Mol Biol 2015; 145:75-84
• Richter S, Peitzsch M, Rapizzi E, Lenders JW, Qin N, de Cubas AA, Schiavi F, Rao JU, Beuschlein F, Quinkler M, Timmers HJ, Opocher G, Mannelli M, Robledo M, Eisenhofer G. Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.J Clin Endocrinol Metab. 2014; 99(10):3903-11
• Weismann D, Peitzsch M, Raida A, Prejbisz A, Gosk M, Riester A, Willenberg HS, Klemm R, Manz G, Deutschbein T, Kroiss M, Darr R, Bidlingmaier M, Januszewicz A, Eisenhofer G, Fassnacht M. Measurements of plasma metanephrines by immunoassay vs liquid chromatography with tandem mass spectrometry for diagnosis of pheochromocytoma.Eur J Endocrinol. 2014; 172(3):251-60
• Juratli TA*, Peitzsch M*, Geiger K, Schackert G, Eisenhofer G, Krex, Dietmar. Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas.Neuro Oncol 2013; 15(6):682-90
• Peitzsch M, Prejbisz A, Kroiss M, Beuschlein F, Arlt W, Januszewicz A, Siegert G, Eisenhofer G. Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultra performance liquid chromatography - tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma.Ann Clin Biochem 2013; 50(2):147-55
• Peitzsch M, Pelzel D, Glockner S, Prejbisz A, Fassnacht M, Beuschlein F, Januszewicz A, Siegert G, Eisenhofer G. Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites. Clin Chim Acta 2013; 418:50-8

Dr. Sofia Traikov

• Jaschke NP, Breining D, Hofmann M, Pählig S, Baschant U, Oertel R, Traikov S, Grinenko T, Saettini F, Biondi A, Stylianou M, Bringmann H, Zhang C, Yoshida TM, Weidner H, Poller WC, Swirski FK, Göbel A, Hofbauer LC, Rauner M, Scheiermann C, Wang A, Rachner TD. Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response. Immunity. 2024 Feb 13;57(2):364-378.e9. doi: 10.1016/j.immuni.2024.01.005. Epub 2024 Jan 31.

•  Anastasia Shatilovich, Vamshidhar R. Gade, Martin Pippel, Tarja T. Hoffmeyer, Aleksei V. Tchesunov, Lewis Stevens, Sylke Winkler, Graham Hughes, Sofia Traikov, Gene Myers, Michael Hiller, Elizaveta Rivkina, Philipp H. Schiffer, Teymuras V. Kurzchalia. Nematodes can survive long geological times in a suspended form of life. PLoS Genet. 2023 Jul 27;19(7):e1010798. doi: 10.1371/journal.pgen.1010798. eCollection 2023 Jul.

•  Keiichi Katsumoto, Siham Yennek, Chunguang Chen, Luis Fernando Delgadillo Silva, Sofia Traikov, Dror Sever,  Ajuna Azad, Akiko Nakamura, Rashmiparvathi Keshara, Jingdong Shan, Seppo Vainio, Nikolay Ninov, Stephan Speier, Anne Grapin-Botton. Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling and function. Nat Commun. 2022 Oct 21;13(1):6255.doi:10.1038/s41467-022-33841-5.

•  Anneline Pinson, Lei Xing, Takashi Namba, Nereo Kalebic, Jula Peters, Christina Eugster-Oegema, Sofia Traikov, Katrin Reppe, Stephan Riesenberg, Tomislav Maricic, Razvan Derihaci, Pauline Wimberger, Svante Pääbo, Wieland B Huttner. A single modern human-specific amino acid substitution in Transketolase-like 1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science. 2022 Sep 9;377(6611):eabl6422. doi: 10.1126/science.abl6422. Epub 2022 Sep 9.

•  Oskar Knittelfelder, Sofia Traikov, Olga Vvedenskaya, Andrea Schuhmann, Sandra Segeletz, Anna Shevchenko, Andrej Shevchenko. Shotgun Lipidomics Combined with Laser Capture Microdissection: A Tool To Analyze Histological Zones in Cryosections of Tissues. Anal. Chem. 2018, 90, 9868−9878

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