Benutzerspezifische Werkzeuge

Metabolic Control

Mirtschink

Dr. Peter Mirtschink

Principal Investigator

Research focus

Cellular stress, in response to inflammatory stimuli or tissue hypoxia leads to profound metabolic remodeling mediated by specific transcriptional and epigenetic determinants. On the other hand metabolic alterations themselves can reshape the transcriptome and epigenome of a cell. By using integrated transcriptomic, epigenomic, metabolomic and lipidomic approaches we aspire to decipher those intertwining mechanisms in order to improve the current understanding of common disease types and their molecular underpinnings.

Specific expertise

  • Specific expertise
  • Cell metabolism
  • Cardio-metabolic disease
  • Gene regulatory cues
  • Integrated-omics 

Funding

dfg_logo_schriftzug_blau_foerderung_4c.jpg

BMBF

DGKLKosing Stiftung

Astrazeneca

  

Lab Members

Dr. Mirtschink, PeterGroup leader
Dr. Katrin StaßburgerPostdoc
Dr. Alexia Belavgeni  Postdoc
Paul Meyfarth  PhD Student

Selected Publications

  • von Renesse J, Mirtschink P. Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia. Signal Transduction and Targeted Therapy8: 383 (2023)

  • Mirtschink P, Neumeister V, Menschikowski M, Suliman R, Wolf G, Kade J, Tiebel O, Poitz DM. 2nd generation of soluble transferrin receptor assay – Consequences for the interpretation of the ‘Thomas’ plot. Journal of Laboratory Medicine47: 275-278 (2023)
  • Perakakis N, Harb H, Hale BG, Varga Z, Steenblock C, Kanczkowski W, Alexaki VI, Ludwig B, Mirtschink P, Solimena M, Toepfner N, Zeissig S, Gado M, Abela IA, Beuschlein F, Spinas GA, Cavelti-Weder C, Gerber PA, Huber M, Trkola A, Puhan MA, Wong WW, Linkermann A, Mohan V, Lehnert H, Nawroth P, Chavakis T, Mingrone G, Wolfrum C, Zinkernagel AS, Bornstein SR. Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases. Lancet Diabetes & Endocrinology11: 675-693 (2023)
  • von Renesse J, von Bechtolsheim F, Jonas S, Seifert L, Alves TC, Seifert AM, Komorek F, Tritchkova G, Menschikowski M, Bork U, Meisterfeld R, Distler M, Chavakis T, Weitz J, Funk AM#, Kahlert C#, Mirtschink P#. Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patients revealed by longitudinal metabolomics. Journal of Cachexia, Sarcopenia & Muscle14: 298-309 (2023)
  • Bischof C#, Mirtschink P#, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J. Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Science Translational Medicine13: eabi7964.K (2021)
  • Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche N, Dahl A, Ian H, Subramanian P, Wielockx B , Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate immune training of granulopoiesis promotes anti-tumor activity. Cell183: 771–785 (2020)
  • Mirtschink, P, Bischof, C, Pham, M D, Sharma, R, Khadayate, S, Rossi, G, Fankhauser, N, Traub, S, Sossalla, S, Hagag, E, Berthonneche, C, Sarre, A, Stehr, S N, Grote, P, Pedrazzini, T, Dimmeler, S, Krek, W and Krishnan, J. Inhibition of the Hypoxia-Inducible Factor 1alpha-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease. Circulation139: 2778-2792 (2019)
  • Mirtschink, P, Jang, C, Arany, Z and Krek, W. Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease. Eur Heart J39: 2497-2505 (2018)
  • Mitroulis, I, Ruppova, K, Wang, B, Chen, L S, Grzybek, M, Grinenko, T, Eugster, A, Troullinaki, M, Palladini, A, Kourtzelis, I, Chatzigeorgiou, A, Schlitzer, A, Beyer, M, Joosten, L A B, Isermann, B, Lesche, M, Petzold, A, Simons, K, Henry, I, Dahl, A, Schultze, J L, Wielockx, B, Zamboni, N, Mirtschink, P, Coskun, U, Hajishengallis, G, Netea, M G and Chavakis, T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell172: 147-161 e12 (2018)
  • Mirtschink, P, Krishnan, J, Grimm, F, Sarre, A, Horl, M, Kayikci, M, Fankhauser, N, Christinat, Y, Cortijo, C, Feehan, O, Vukolic, A, Sossalla, S, Stehr, S N, Ule, J, Zamboni, N, Pedrazzini, T and Krek, W. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature522: 444-449 (2015)
  • Krishnan, J, Danzer, C, Simka, T, Ukropec, J, Walter, K M, Kumpf, S, Mirtschink, P, Ukropcova, B, Gasperikova, D, Pedrazzini, T and Krek, W. Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev26: 259-70 (2012)

#equal authorship