Benutzerspezifische Werkzeuge

Metabolic Control

Mirtschink

Dr. Peter Mirtschink

Group Leader


Research focus

Cellular stress, in response to inflammatory stimuli or tissue hypoxia leads to profound metabolic remodeling mediated by specific transcriptional and epigenetic determinants. On the other hand metabolic alterations themselves can reshape the transcriptome and epigenome of a cell. By using integrated transcriptomic, epigenomic, metabolomic and lipidomic approaches we aspire to decipher those intertwining mechanisms in order to improve the current understanding of common disease types and their molecular underpinnings.

Specific expertise

  • Specific expertise
  • Cell metabolism
  • Cardio-metabolic disease
  • Gene regulatory cues
  • Integrated-omics

Lab Members

Hagag, EmanPhD student
Heller, PaulMD student
Dr. Mirtschink, PeterGroup leader
Witt, AnkePhD student

Selected Publications

  • Mirtschink, P, Bischof, C, Pham, M D, Sharma, R, Khadayate, S, Rossi, G, Fankhauser, N, Traub, S, Sossalla, S, Hagag, E, Berthonneche, C, Sarre, A, Stehr, S N, Grote, P, Pedrazzini, T, Dimmeler, S, Krek, W and Krishnan, J. Inhibition of the Hypoxia-Inducible Factor 1alpha-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease. Circulation139: 2778-2792 (2019)
  • Mirtschink, P, Jang, C, Arany, Z and Krek, W. Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease. Eur Heart J39: 2497-2505 (2018)
  • Mitroulis, I, Ruppova, K, Wang, B, Chen, L S, Grzybek, M, Grinenko, T, Eugster, A, Troullinaki, M, Palladini, A, Kourtzelis, I, Chatzigeorgiou, A, Schlitzer, A, Beyer, M, Joosten, L A B, Isermann, B, Lesche, M, Petzold, A, Simons, K, Henry, I, Dahl, A, Schultze, J L, Wielockx, B, Zamboni, N, Mirtschink, P, Coskun, U, Hajishengallis, G, Netea, M G and Chavakis, T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell172: 147-161 e12 (2018)
  • Mirtschink, P, Krishnan, J, Grimm, F, Sarre, A, Horl, M, Kayikci, M, Fankhauser, N, Christinat, Y, Cortijo, C, Feehan, O, Vukolic, A, Sossalla, S, Stehr, S N, Ule, J, Zamboni, N, Pedrazzini, T and Krek, W. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature522: 444-449 (2015)
  • Krishnan, J, Danzer, C, Simka, T, Ukropec, J, Walter, K M, Kumpf, S, Mirtschink, P, Ukropcova, B, Gasperikova, D, Pedrazzini, T and Krek, W. Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev26: 259-70 (2012)