Benutzerspezifische Werkzeuge

Hypoxia and Haematopoiesis

Platzhalter Bild

Prof. Dr. Ben Wielockx

Group leader


Research focus

All cells in our body depend on an appropriate oxygen pressure (pO2) to function. That’s why an inadequate oxygen supply (=hypoxia) is a prominent feature in various diseased tissues. During the past decade, research in our group is focused on unraveling the influence of hypoxia pathway proteins in physiological and pathological conditions, including cancer, inflammation, and a variety of processes in the bone/bone marrow environment, especially hematopoietic stem cell (HSC) maintenance.

In parallel, we are studying other fundamental questions related to HSC fate decisions as a consequence of external stress and in the context of the bone marrow niche.

Specific expertise

  • Inflammatory mouse models
  • Hematopoiesis
  • Tumor biology
  • Mouse genetics

Funding

Twitter

 @UHSI-Team

Lab Members

Gaete, DianaPhD student
Dr. Grinenko, TatyanaMSNZ Junior Group Leader
Hammad, DanMedical student
Ibneeva, LiliiaPhD student
Krüger, AnjaLab manager
Rodriguez, DiegoPhD student
Dr. Sormendi, SundaryScientific Manager
Stein, JohannaTechnician
Dr. Watts, DeepikaPostdoc
Prof. Dr. Wielockx, BenGroup leader

Selected Publications

  • Ramasz, B, Kruger, A, Reinhardt, J, Sinha, A, Gerlach, M, Gerbaulet, A, Reinhardt, S, Dahl, A, Chavakis, T, Wielockx, B and Grinenko, T. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood134: 1046-1058 (2019)
  • Grinenko, T, Eugster, A, Thielecke, L, Ramasz, B, Kruger, A, Dietz, S, Glauche, I, Gerbaulet, A, von Bonin, M, Basak, O, Clevers, H, Chavakis, T and Wielockx, B. Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice. Nat Commun9: 1898 (2018)
  • Singh, R P, Grinenko, T, Ramasz, B, Franke, K, Lesche, M, Dahl, A, Gassmann, M, Chavakis, T, Henry, I and Wielockx, B. Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice. Stem Cell Reports10: 1908-1919 (2018)
  • Mitroulis, I, Chen, L S, Singh, R P, Kourtzelis, I, Economopoulou, M, Kajikawa, T, Troullinaki, M, Ziogas, A, Ruppova, K, Hosur, K, Maekawa, T, Wang, B, Subramanian, P, Tonn, T, Verginis, P, von Bonin, M, Wobus, M, Bornhauser, M, Grinenko, T, Di Scala, M, Hidalgo, A, Wielockx, B, Hajishengallis, G and Chavakis, T. Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest127: 3624-3639 (2017)
  • Rauner, M, Franke, K, Murray, M, Singh, R P, Hiram-Bab, S, Platzbecker, U, Gassmann, M, Socolovsky, M, Neumann, D, Gabet, Y, Chavakis, T, Hofbauer, L C and Wielockx, B. Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells. J Bone Miner Res31: 1877-1887 (2016)