Benutzerspezifische Werkzeuge

Inflammation and Myelopoiesis

Junior Prof. Dr. Lydia Kalafati

Dr. Lydia Kalafati 

Principal Investigator

Platzhalter Bild

                                    

                                          

Under Construction

 

Lab Members

Dr. Lydia KalafatiJunior Group Leader
Sidiropoulos, Panagiotis PhD student

Selected Publications

  • Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell. 2022 May 12;185(10):1709-1727.
  • Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020 Oct 29;183(3):771-785.e12.
  • Kalafati L, Hatzioannou A, Hajishengallis G, Chavakis T  The role of neutrophils in trained immunity. Immunol Rev. 2023 Mar;314(1):142-157. Review.
  • Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, Lim JH, Alexaki VI, Ktistakis NT, Doskas T, Garinis GA, Chavakis T, Boumpas DT, Verginis P. Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity. Cell Metab. 2020 Oct 6;32(4):591-604.e7. 
  • Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T . Regulation of the Bone Marrow Niche by Inflammation. Front Immunol. 2020 Jul 21;11:1540. Review.
  • Moorlag SJCFM, Rodriguez-Rosales YA, Gillard J, Fanucchi S, Theunissen K, Novakovic B, de Bont CM, Negishi Y, Fok ET, Kalafati L, Verginis P, Mourits VP, Koeken VACM, de Bree LCJ, Pruijn GJM, Fenwick C, van Crevel R, Joosten LAB, Joosten I, Koenen H, Mhlanga MM, Diavatopoulos DA, Chavakis T, Netea MG BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils. Cell Rep. 2020 Nov 17;33(7):108387..
  • Jentho E, Ruiz-Moreno C, Novakovic B, Kourtzelis I, Megchelenbrink WL, Martins R, Chavakis T, Soares MP, Kalafati L, Guerra J, Roestel F, Bohm P, Godmann M, Grinenko T, Eugster A, Beretta M, Joosten LAB, Netea MG, Bauer M, Stunnenberg HG, Weis. Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. S.Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2102698118
  • Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T . Myelopoiesis in the Context of Innate Immunity. J Innate Immun. 2018;10(5-6):365-372. Review.
  • Kalafati L, Mitroulis I, Verginis P, Chavakis T, Kourtzelis I. Neutrophils as Orchestrators in Tumor Development and Metastasis Formation. Front Oncol. 2020 Dec 10;10:581457. Review