Forschung - Research

In research, the Institute for Clinical Chemistry and Labarotory medicine is focused on the investigation of the regulation of immunological processes as well as  the interaction between inflammation, metabolism and haematopoiesis. The institute's research projects deal with the process of leukocyte recruitment, the activation of innate immunity cells , the regulation of blood formation, cell metabolism, especially of immune cells, and hypoxia-induced processes in various inflammatory-metabolic diseases. In addition, the institute's research focuses on the neurochemical analysis of endocrine diseases and epigenetic mechanisms. 

Research Labs

• Epigenetics (Prof.Dr. Mario Menschikowski)
• Hypoxia and Haematopoiesis (Prof. Dr. Ben Wielockx)
• Innate Immunity and Metabolic Inflammation (Prof. Dr. Triantafyllos Chavakis) 
•  Membrane Biochemistry  and Lipid research (Prof. Dr. Ünal Coskun) 
• Metabolic Control (Dr. Peter Mirtschink) 
• Metabolic Regulation and Cell Function (Dr. Tiago Alves)
• Neurochemistry (Prof. Dr. Graeme Eisenhofer) 
• Neurroinflammation ( Dr. Vasileia ismini Alexaki)
• Translational Oncology (Dr. Mohamed Elgendy)  

Latest Publications

•  Thangapandi, V R, Knittelfelder, O, Brosch, M, Patsenker, E, Vvedenskaya, O, Buch, S, Hinz, S, Hendricks, A, Nati, M, Herrmann, A, Rekhade, D R, Berg, T, Matz-Soja, M, Huse, K, Klipp, E, Pauling, J K, Wodke, J A, Miranda Ackerman, J, Bonin, M V, Aigner, E, Datz, C, von Schonfels, W, Nehring, S, Zeissig, S, Rocken, C, Dahl, A, Chavakis, T, Stickel, F, Shevchenko, A, Schafmayer, C, Hampe, J and Subramanian, P. Loss of hepatic Mboat7 leads to liver fibrosis. Gut(2020).                                                                                                                                                                                               https://gut.bmj.com/content/gutjnl/early/2020/06/25/gutjnl-2020-320853.full.pdf

•  Kourtzelis, I, Hajishengallis, G and Chavakis, T. Phagocytosis of Apoptotic Cells in Resolution of Inflammation. Front Immunol 11: 553 (2020).                                                                                                                                                                     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137555/

•  Pyrina, I, Chung, K J, Michailidou, Z, Koutsilieris, M, Chavakis, T and Chatzigeorgiou, A. Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation. Front Cell Dev Biol 8: 644 (2020).                                                                            https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372115/

•  Troullinaki, M, Chen, L S, Witt, A, Pyrina, I, Phieler, J, Kourtzelis, I, Chmelar, J, Sprott, D, Gercken, B, Koutsilieris, M, Chavakis, T and Chatzigeorgiou, A. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J 34: 3336-3346 (2020)                                                                                         .https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.201900125RR

•  Ziogas, A, Maekawa, T, Wiessner, J R, Le, T T, Sprott, D, Troullinaki, M, Neuwirth, A, Anastasopoulou, V, Grossklaus, S, Chung, K J, Sperandio, M, Chavakis, T, Hajishengallis, G and Alexaki, V I. DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1. J Immunol 204: 1214-1224 (2020).                                                                    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026770/

•  Kourtzelis, I, Li, X, Mitroulis, I, Grosser, D, Kajikawa, T, Wang, B, Grzybek, M, von Renesse, J, Czogalla, A, Troullinaki, M, Ferreira, A, Doreth, C, Ruppova, K, Chen, L S, Hosur, K, Lim, J H, Chung, K J, Grossklaus, S, Tausche, A K, Joosten, L A B, Moutsopoulos, N M, Wielockx, B, Castrillo, A, Korostoff, J M, Coskun, U, Hajishengallis, G and Chavakis, T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol 20: 40-49 (2019).                               https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291356/

•  Ramasz, B, Kruger, A, Reinhardt, J, Sinha, A, Gerlach, M, Gerbaulet, A, Reinhardt, S, Dahl, A, Chavakis, T, Wielockx, B and Grinenko, T. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood 134: 1046-1058 (2019).                                                                                                                             https://ashpublications.org/blood/article-lookup/doi/10.1182/blood.2019000721