Subprojects
Subproject 1
Inflammasome-associated defects of cytoplasmatic DAMP recognition - Effects of CASP1 gene mutations on transcription, cytokine release patterns and pyroptosisRead More
Subproject 2
Mapping dynamic protein interactions of Receptor interacting protein 2 (RIP2), Pro-Caspase-1, ASC and other CARD-proteins using life-cell imagingRead More
Subproject 4
The role of the Trex1-, RNase H2- and SAMHD1-associated intracellular nucleic acid metabolism during restriction of retroelements - implications for the pathogenesis of systemic autoimmunityRead More
Subproject 5
The role of defects in nucleic acid metabolism for the pathogenesis of cutaneous autoimmune diseasesRead More
Subproject 6
Aicardi-Goutières Syndrom-associated gene products as potential sensors or antiviral effectors for exogenous virusesRead More
Subproject 7
Pathogenetic mechanisms in autoimmunity induced by deregulated zytosolic nucleic-acid recognitionRead More
Subproject Z
Central management, structured scientific training and doctoral program for medical studentsRead More