Molecular mechanisms of nucleic acid recognition

TRR237

DZKJ

Mishra, H., Schlack-Leigers, C., Lim, E.L., Thieck, O., Magg, T., Raedler, J., Wolf, C., Klein, C., Ewers, H., Lee-Kirsch, M.A., Meierhofer, D., Hauck, F., Majer, O., 2024. Disrupted degradative sorting of TLR7 is associated with human lupus. Sci Immunol. 9, eadi9575. https://doi.org/10.1126/sciimmunol.adi9575

Wolf, C., Lim, E.L., Mokhtari, M., Kind, B., Odainic, A., Lara-Villacanas, E., Koss, S., Mages, S., Menzel, K., Engel, K., Dückers, G., Bernbeck, B., Schneider, D.T., Siepermann, K., Niehues, T., Goetzke, C.C., Durek, P., Minden, K., Dörner, T., Stittrich, A., Szelinski, F., Guerra, G.M., Massoud, M., Bieringer, M., De Oliveira Mann, C.C., Beltrán, E., Kallinich, T., Mashreghi, M.-F., Schmidt, S.V., Latz, E., Klughammer, J., Majer, O., Lee-Kirsch, M.A., 2024. UNC93B1 variants underlie TLR7-dependent autoimmunity. Sci Immunol. 9, eadi9769. https://doi.org/10.1126/sciimmunol.adi9769

Günther, C., Wolf, C., Fennen, L., Rösing, S., Beissert, S., Aringer, M., Lee-Kirsch, M.A., 2023. Case Report: Response of cutaneous lupus lesions in SLE to interferon receptor blockade parallels reduction of interferon score in blood. Front Immunol. 14, 1253279. https://doi.org/10.3389/fimmu.2023.1253279, open access

Wolf, C., Fischer, H., Kühl, J.-S., Koss, S., Jamra, R.A., Starke, S., Schultz, J., Ehl, S., Neumann, K., Schuetz, C., Huber, R., Hornung, V., Lee-Kirsch, M.A., 2023. Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9. J Allergy Clin Immunol. 152, 1336-1344.e5. https://doi.org/10.1016/j.jaci.2023.07.013, open access

Berndt, N., Wolf, C., Fischer, K., Cura Costa, E., Knuschke, P., Zimmermann, N., Schmidt, F., Merkel, M., Chara, O., Lee-Kirsch, M.A., Günther, C., 2022. Photosensitivity and cGAS-dependent IFN-1 activation in patients with lupus and TREX1 deficiency. J Invest Dermatol. 142, 633-640.e6. https://doi.org/10.1016/ j.jid.2021.04.037, open access

Wolf, C., Brück, N., Koss, S., Griep, C., Kirschfink, M., Palm-Beden, K., Fang, M., Röber, N., Winkler, S., Berner, R., Latz, E., Günther, C., Lee-Kirsch, M.A., 2020. Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol. 146, 1439-1442.e5. https://doi.org/10.1016/j.jaci.2020.04.002, open access

Zimmermann, N., Wolf, C., Schwenke, R., Lüth, A., Schmidt, F., Engel, K., Lee-Kirsch, M.A., Günther, C., 2019. Assessment of clinical response to Janus kinase inhibition in patients with familial chilblain lupus and TREX1 mutation. JAMA Dermatol. 155, 342. https://doi.org/10.1001/jamadermatol.2018.5077, open access

König, N., Fiehn, C., Wolf, C., Schuster, M., Cura Costa, E., Tüngler, V., Alvarez, H.A., Chara, O., Engel, K., Goldbach-Mansky, R., Günther, C., Lee-Kirsch, M.A., 2017. Familial chilblain lupus due to a gain-of-function mutation in STING. Ann Rheum Dis. 76, 468–472. https://doi.org/10.1136/annrheumdis-2016-209841

Wolf, C., Rapp, A., Berndt, N., Staroske, W., Schuster, M., Dobrick-Mattheuer, M., Kretschmer, S., König, N., Kurth, T., Wieczorek, D., Kast, K., Cardoso, M.C., Günther, C., Lee-Kirsch, M.A., 2016. RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat Commun. 7, 11752. https://doi.org/10.1038/ncomms11752, open access

Kretschmer, S., Wolf, C., König, N., Staroske, W., Guck, J., Häusler, M., Luksch, H., Nguyen, L.A., Kim, B., Alexopoulou, D., Dahl, A., Rapp, A., Cardoso, M.C., Shevchenko, A., Lee-Kirsch, M.A., 2015. SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis. 74, e17. https://doi.org/10.1136/annrheumdis-2013-204845, open access