Benutzerspezifische Werkzeuge

Projects

1st Summer School of the European Society for Microcirculation (ESM) and the European Vascular Biology Organization (EVBO

Project leaders: H. Morawietz, R. Siow (https://www.uniklinikum-dresden.de/de/das-klinikum/kliniken-polikliniken-institute/mk3/experimentelle-bereiche/bereich-gefasendothel-und-mikrozirkulation/summer_school)

Funding: Excellence Initiative by the German Federal and State Governments, TU Dresden’s Internationalisation Strategy (ZUK 64/1)

Aim: The European Society for Microcirculation (ESM) and the European Vascular Biology Organization (EVBO) support the research on blood vessels, vascular cells and corresponding clinical complications like myocardial infarction and stroke. In order to support young investigators in the field we have established in collaboration with Prof. Richard Siow from King’s College London the 1st ESM/EVBO Summer School. The developed concept teach young MD/PhD students at an early stage of their scientific career in cutting edge research from leading international scientists in the field, modern methods of vascular biology and medicine and important skills to publish their results and to get funding for their projects to become successful scientists in the field.

International PhD Program Homeostatic and regulatory functions of endothelium

Project leader: H. Morawietz (http://tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/ehd)

Funding: Excellence Initiative by the German Federal and State Governments, TU Dresden’s Support-the-best-Program

Aim: The vascular endothelium has not only a structural function as inner layer of the vessel wall, but is also considered as independent organ system with important metabolic functions. Endothelial dysfunction is a central factor in the development of cardiovascular diseases like hypertension or atherosclerosis and metabolic diseases like diabetes. The endothelium is central focus of this English international PhD Program, which provides PhD students in addition to their experimental PhD thesis project a structured scientific education.

Impact of a mineralocorticoid receptor blockade on vascular function in an atherosclerotic mouse model

Project leader: H. Morawietz

Funding: Doktor Robert Pfleger-Stiftung

Aim: In this project, we study the impact of a mineralocorticoid receptor blockade and LOX-1 overexpression on parameters of the metabolic syndrome and the vascular function in an experimental mouse model of atherosclerosis.

Determination of enzyme concentration in PPP study samples

Project leaders: C. Brunßen, H. Morawietz

Funding: Noxygen Science Transfer & Diagnostics GmbH

Aim: In this project we analyze enzyme concentrations in PPP study samples.

Study to investigate metabolic outcome of aldosterone synthase inhibition in an obese mouse model of type 2 diabetes

Project leaders: H. Morawietz, H. Willenberg, S. R. Bornstein

Funding: Boehringer-Ingelheim Pharma GmbH & Co. KG

Aim: In this project we investigate the impact of aldosterone synthase inhibition on metabolic parameters in an experimental model of type 2 diabetes.

Aldosteron, LOX-1 and adipose tissue

Project leaders: A. Leuner, H. Morawietz

Funding: European Section of the Aldosterone Council (ESAC) Deutschland, Verein zur Förderung der Aldosteron-Forschung e.V.

Aim: In this project we investigate the LOX-1 expression in response to aldosterone and the interaction of both factors in adipose tissue.

Aldosteron, LOX-1 and endothelial function

Project leader: H. Morawietz

Funding: Else Kröner-Fresenius-Stiftung

Aim: In this project we analyze the regulation of LOX-1 und the importance of aldosterone and LOX-1 in endothelial dysfunction and atherosclerosis.

International PhD program „Endothelium in health and disease“

Project leader: A. Deußen, vice-speaker: H. Morawietz
(http://www.tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/ehd)

Funding: DAAD

Aim: The vascular endothelium plays a central role in the regulation of different physiological and pathophysiological processes in vascularized organs. This affects the cardiovascular system, but also diseases of the immune system, metabolic and neuronal disorders, or cancer. The central importance of the endothelium is the thematic focus of this international PhD program.

Engraftment, function and beta cell regulation in the adrenal transplant model

Project leaders: B. Ludwig, H. Morawietz, S. R. Bornstein

Funding: DFG, KFO 252 (http://www.uniklinikum-dresden.de/das-klinikum/kliniken-polikliniken-institute/kfo-252)

Aim: Engraftment and re-vascularization are key factors in human pancreatic islet transplantation. The microenvironment of the adrenal gland features potentially ideal characteristics as a novel transplant site which will be analyzed here using a murine and a large animal model of islet transplantation.

Hemodynamic regulation of Nox4 in the endothelium

Project leader: H. Morawietz

Funding: DFG

Aim: Aim of this project is a better understanding of the molecular mechanisms of the hemodynamic regulation of NAD(P)H oxidase subunit Nox4 by shear stress and strain. Based on this knowledge we hope to develop new strategies for the prevention and therapy of endothelial dysfunction and cardiovascular diseases.

Proarteriosclerotic interaction of oxidative stress, oxidatively modified low-density lipoprotein, angiotensin II and endothelin-1 in human endothelial cells

Project leader: H. Morawietz

Funding: Doktor Robert Pfleger-Stiftung

Aim: In this project, the proarteriosclerotic importance of native and oxidized low-density lipoprotein for the induction of oxidative stress and the release of angiotensin II and endothelin-1 will be studied in human endothelial cells.

EXC 168: Regenerative Therapies: From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration

Project leader: M. Brandt, Participants: u.a. H. Morawietz
(http://www.crt-dresden.de/institutions.html)

Funding: DFG

Aim: The molecular biosciences provide unique prospects to enhance tissue and organ regeneration. Our goal is to develop advanced treatments for haemato-oncological, neurodegenerative, diabetic, bone and cardiovascular diseases.

DFG Research Center "Centre for Regenerative Therapies Dresden” (CRTD)

Project leader: M. Brandt, CRTD Participants: e.g. H. Morawietz
(http://www.crt-dresden.de/institutions.html)

Funding: DFG

Aim: Dresden has outstanding expertise in the life science disciplines (medicine, molecular cell and developmental biology, stem cell research, genomics, proteomics, bioinformatics) and engineering (tissue engineering, biomaterials science, chemistry, nanotechnology), providing a fertile ground for a broad interdisciplinary effort towards developing regenerative therapies. The DFG research centre will capitalize on basic research in regenerating model organisms to understand stem cell recruitment, activation, proliferation, homing and differentiation, and will apply this knowledge to control these cellular processes using genetics, surface engineering and micro devices in order to elicit regenerative responses.

Endothelium and cardiovascular diseases

Project leader: H. Morawietz, Stipendiary: A. Arsov
http://www.dresden-ipp.de

Funding: DFG, Excellence initiative by the German federal and state governments to promote science and research at German Universities, PhD Program „Dresden International Graduate School for Biomedicine and Bioengineering“
Aim: In this project we will analyze the regulation of oxidative stress in endothelial cells and its importance for vascular function and cardiovascular diseases.

GSC 97: Dresden International Graduate School for Biomedicine and Bioengineering

Project leader: G. Rödel, Participants: e.g. H. Morawietz
(http://www.dresden-ipp.de/research/research_groups/henning_morawietz.html)

Funding: DFG, Excellence initiative by the German federal and state governments to promote science and research at German Universities, PhD Program „Dresden International Graduate School for Biomedicine and Bioengineering“
Aim: The Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) has the aim to develop and further improve an internationally recognized centre of PhD graduation in biomedicine and bioengineering and to offer excellent students from all over the world optimal conditions on their way to the PhD degree.

Obesity, LOX-1, vascular structure and endothelial function

Project leader: H. Morawietz

Funding: Doktor Robert Pfleger-Stiftung

Aim: In this project we will analyze the induction of LOX-1 in human endothelial cells and the impact of obesity by high-fat diet on vascular gene expression in an atherosclerosis model. These studies will contribute to a better understanding of the role of LOX-1 as potential therapeutic target in obesity-mediated development of atherosclerosis.

Regulation of oxidative stress in endothelial cells

Structural measures and directed planning of improvement of clinical research at the Medical Faculty Carl Gustav Carus in Dresden (3rd phase of support, prolongation), Project C3-Professorship Vascular Endothelium and Microcirculation

Project leader: H. Morawietz

Funding: German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung)
Aim: In this project, the importance of oxidative stress in the development of cardiovascular diseases is analyzed in experimental and clinical studies. A major focus is the endothelial NAD(P)H oxidase.