Benutzerspezifische Werkzeuge

PhD student in Immunology/Cell Biology (f/m/x)

At the Institute of Physiological Chemistry of the TU Dresden in the group of Prof. Dr. Bernd Schröder we are looking for a

PhD student in Immunology/Cell Biology (f/m/x) 

The position is available from 01.01.2022.

Our group works on intramembrane proteolysis which links protein degradation with signal transduction and thus represents an important regulatory mechanism for cellular homeostasis. We are especially interested in the SPP/SPPL family of intramembrane proteases. One member of this protease family, SPPL2a, is of crucial importance for development and function of B cells and dendritic cells in mice. Recently, also human patients with SPPL2a deficiency were identified to lack certain dendritic cells and to be susceptible to mycobacterial infections. These phenotypes have been linked with a the SPPL2a substrate CD74 which accumulates in the absence of the protease. However, we recently found that also other members of the SPP/SPPL protease family impact on immune cells via additional, currently unpublished substrates. 

In the planned PhD project, we want to further characterize the impact of SPP/SPPL proteases on immune cell development and function in more detail. Therefore, the PhD project will combine basic biochemical/cell biological approaches with the extensive analysis of primary immune cells from our different mouse models. The project offers a broad spectrum of experimental techniques and is at the interface of answering fundamental cell biological/immunological questions in conjunction with characterizing in the underlying mechanism in certain human diseases.

Your Profile:

  • You hold a Masters degree in biochemistry, biology or related subjects
  • You have experimental experience in one of the following areas: immunology, molecular biology, biochemistry, cell biology
  • You are a great team worker
  • You enjoy studying fundamental questions in biology and doing science

We offer:

  • An exciting research project with high translational relevance
  • Ability to learn and apply a broad spectrum of methods from biochemistry, cell biology and immunology
  • Integration into a highly motivated team in a well-equipped institute
  • A Position according to the TV-L conditions

For further information click here.

  • Schneppenheim et al. & Schröder, J Exp. Med 2013
  • Mentrup et al. & Schröder, J Exp. Med 2019
  • Mentrup et al. & Schröder, Cell Mol Life Sci 2020

Applications of all genders are appreciated. Disabled persons with equal qualifications are preferred.

We kindly ask you to apply via our online form with registration Number PCH0921809 until December, 13th 2021 to make the selection process faster and more effective. Your application should include your CV, relevant certificates/degrees, a brief summary of your previous scientific experience, a short statement why you chose to apply for this position and, if available, contact information of two referees. For further information please contact Prof. Bernd Schröder by phone +49(0) 351-458-6450 or via e-mail: bernd.schroeder@tu-dresden.de