Benutzerspezifische Werkzeuge

PhD student (f/m/x)

The Center for Regenerative Therapies Dresden (CRTD) is a research center at the TU Dresden with currently over 20 research groups and more than 250 employees. Research at the CRTD focuses on regenerative and stem cell research ranging from basic research to application in a clinical-translational context. Scientists at the CRTD are working in the fields of hematology/immunology, diabetes, neurodegenerative diseases and bone and tissue regeneration.

The research group of Prof. Sebastian Zeissig is seaking for a highly motivated

PhD student (f/m/x) 

for the study of microbial triggers of intestinal inflammation

The position is integrated into the DFG Collaborative Research Center 1371 "Microbiome Signatures" and will start April 1st, 2023 (or as early as possible).

In this project, you will join the Mucosal Immunology Lab at the Center for Regenerative Therapies Dresden (Prof. Sebastian Zeissig) to investigate how alterations in host-microbial interactions can elicit chronic intestinal inflammation in inflammatory bowel disease (IBD). We have previously identified pathways through which host genetic defects can provide susceptibility to microbiota-dependent intestinal inflammation (Strigli, Gopalakrishnan et al., Sci Immunol 2021). Based on this work, you will be applying gnotobiotic mice carrying human microbiota to identify microbial triggers of intestinal inflammation. Furthermore, using Primary human and murine intestinal organoids, co-cultures with bacteria, and state-of-the-art approaches such as scRNA- and spatial RNA sequencing, you will study the mechanisms responsible for development of intestinal inflammation. The long-term vision of this project is to establish microbiome-based approaches for the prevention and treatment of IBD in genetically susceptible hosts.

References:

1. Peuker K,...., Zeissig S. Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer. Immunity. 2022 Apr 12;55(4):701-717.e7.

2. Strigli A,..., Zeissig S. Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation. Sci Immunol. 2021 Nov 5;6(65):eabf7473.

3. Peuker K, Muff S,…, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016 May;22(5):506-15.

4. Zeissig Y,…, Zeissig S. XIAP variants associated with NOD1/2 dysfunction in pediatric-onset Crohn’s disease. Gut 2015 Jan;64(1):66-76. 

Your Profile:

  • Master’s degree (or equivalent) in Immunology, Microbiology, Molecular Biology, Biotechnology, Animal Science, or any related fields in biological sciences
  • Ideally expertise in the work with mice and basic microbiology and cell culture techniques
  • Ability to work independently, efficiently and goal-oriented
  • Excellent knowledge of the English language

We offer:

  • The position offers an excellent opportunity to join a group of enthusiastic researchers in a cross-disciplinary environment. For more information on the group and the institute please click here.
  • The position is integrated into the DFG Collaborative Research Center 1371 "Microbiome Signatures – Functional Relevance in the Digestive Tract" (Speaker: Prof. Haller, TU Munich, www.sfb1371.tum.de). The CRC 1371 features an Integrated Research Training School (IRTG) which provides a qualification program for PhD students containing excellent multidisciplinary training with tailor-made subject-based and soft skills courses, annual retreats, summer school, and a supervision concept.
  • Payment is according to the wage agreement of the civil service TV-L (65% of E13). Please note that there are no additional postgraduate degree fees required for international candidates.

Disabled persons with equal qualification will be preferred. 

Applicants are asked to send one pdf file to the contact person (sebastian.zeissig@tu-dresden.de). The file should include:

  • cover letter,
  • curriculum vitae,
  • copies of academic degrees and transcripts of records,
  • contact information for at least one letter of recommendation,
  • list of publications (do not include your publications in the pdf file) 

We also consider your written application without any disadvantages. We look forward to receiving your application, until February 15th, 2023 online with registration number CRT0923584. For further information, please contact Prof. Sebastian Zeissig, Center for Regenerative Therapies Dresden (CRTD) and Department of Medicine I, TU Dresden, Fetscherstr. 105, 01307 Dresden, sebastian.zeissig@tu-dresden.de