Benutzerspezifische Werkzeuge

PhD student (f/m/x)

The Center for Regenerative Therapies Dresden (CRTD) is a research center at the TU Dresden with currently over 20 research groups and more than 250 employees. Research at the CRTD focuses on regenerative and stem cell research ranging from basic research to application in a clinical-translational context. Scientists at the CRTD are working in the fields of hematology/immunology, diabetes, neurodegenerative diseases and bone and tissue regeneration.

The research group of Prof. Dr. Sebastian Zeissig is seeking for a highly motivated

PhD student (f/m/x) 

for the study of microbial regulation of colorectal cancer development

starting April 1st, 2023 (or as early as possible).

We have previously demonstrated important contributions of the microbiota to colorectal cancer (CRC) development and progression (Peuker et al., Immunity 2022, Nat. Med. 2016). Based on this work, we aim to identify specific molecular mediators derived from the intestinal microbiota which regulate CRC progression and metastasis. In this project, you will be working with mouse models of orthotopic CRC development, including gnotobiotic mice, to study microbial contributions to CRC progression. Furthermore, you will work with primary human and murine intestinal organoids in 2D and 3D co-cultures to study host-microbial interactions at the cellular level. To identify underlying molecular mechanisms and pathways, scRNA/snRNA and spatial RNA sequencing, metagenomic sequencing, and metabolomic studies will be performed. The long-term goal of this project is to identify druggable host-microbial interactions which promote CRC progression. 

References:

1. Peuker K,...., Zeissig S. Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer. Immunity. 2022 Apr 12;55(4):701-717.e7.

2. Strigli A,..., Zeissig S. Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation. Sci Immunol. 2021 Nov 5;6(65):eabf7473.

3. Peuker K, Muff S,…, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016 May;22(5):506-15.

Your Profile:

  • Master’s degree (or equivalent) in Immunology, Microbiology, Molecular Biology, Biotechnology, Animal Science, or any related fields in biological sciences
  • Ideally expertise in the work with mice and basic microbiology and cell culture techniques
  • Ability to work independently, efficiently and goal-oriented
  • Excellent knowledge of the English language

We offer:

  • Our research group is interested in the crosstalk between inflammation and carcinogenesis in the intestine and the liver.
  • Research follows a translational strategy in which human observations are mechanistically dissected using mouse models, primary human tissues and cell culture approaches.
  • Research is conducted at the Center for Regenerative Therapies TU Dresden (CRTD). For more information about the research of our group, please click here.
  • PhD students will be integrated into the Bioscience PhD Students program. Payment is according to the wage agreement of the civil service TV-L (65% of E13). Please note that there are no additional postgraduate degree fees required for international candidates.

Disabled persons with equal qualification will be preferred. 

Applicants are asked to send one pdf file to the contact person (sebastian.zeissig@tu-dresden.de). The file should include:

  • cover letter,
  • curriculum vitae,
  • copies of academic degrees and transcripts of records,
  • contact information for at least one letter of recommendation,
  • list of publications (do not include your publications in the pdf file) 

We also consider your written application without any disadvantages. We look forward to receiving your application, until February 15th, 2023 online with registration number CRT0923583. For further information, please contact Prof. Sebastian Zeissig, Center for Regenerative Therapies Dresden (CRTD) and Department of Medicine I, TU Dresden, Fetscherstr. 105, 01307 Dresden, sebastian.zeissig@tu-dresden.de