Benutzerspezifische Werkzeuge

PhD student – Early Stage Researcher (ESR1) (f/m/x)

The EU-funded Innovative Training Network FIDELIO aims to train the next generation of scientists in order to tackle the challenges of diabetic bone disease from various angles and with the newest technologies available. Interdisciplinary training and implementation of innovative approaches are key. Within this consortium, we will comprehensively unravel the genetic and environmental mechanisms that contribute to bone fragility in diabetes, identify predictors and clinical markers for patient stratification, decipher the underlying molecular mechanisms of bone fragility in diabetes, and establish potential interventions through a personalised medicine Approach.

The research programme will address different aspects of diabetic bone disease from the viewpoints of epidemiology, genetics, miRNAs, microbiome, bone biology, bone biomechanics and microstructure, preclinical and clinical research. It will utilise advanced imaging and computational approaches, diabetes mouse models and access to clinical cohorts and registry data to obtain a comprehensive overview of how these mechanisms combine in diabetes to cause increased fracture risk. With this interdisciplinary approach, we can explore the impact of biological pathways in mouse models and/or humans, and interactions with diet, exercise and other exposures. Collaborations with industry will allow early identification of IP, access to state of the art technologies, and will complement the academic ESR training programme with entrepreneurship and industrial mentoring. Starting in January 2020 we are looking for a

PhD student – Early Stage Researcher (ESR1) (f/m/x)

(Project: Investigating the role of Wnt signaling in type 2 Diabetes)

You will investigate the regulation of Wnt signaling in type 2 diabetes mellitus (T2D) in the monogenetic db/db mouse as well as the polygenetic TallyHo mouse. The mouse model will be characterized in terms of bone, fat, and  vasculature using state-of-the-art techniques. To determine whether Wnt signaling plays a role in the development of diabetic bone disease, Wnt activators will be applied to cells and mice to determine whether the reduction of bone quality can be restored. Finally, in collaboration with TamiRNA, miRNA profiles will be investigated to determine which miRNAs are associated with diabetic bone disease and target Wnt signaling and whether modulating specific miRNAs may qualify as a therapeutic strategy to treat diabetic bone disease. Candidate miRNAs will be validated in human
cohorts from FIDELIO Partners.

Secondments:
You will embark on secondments to other FIDELIO partners (SCANCO (CH), UKE (GER), ETH (CH)) to access experimental models or tools or receive training not available in the home laboratory. This will include the acquisition, processing and visualization of microCT measurements at higher resolution than available in the Bone Lab, imaging of the osteocyte network, FE-based analysis of bone strength, and bone biomechanics in diabetic mice investigation of the bone vasculature in diabetic mice using corrosion casts and ultraresolution micro-CT imaging. Total secondment time is 5 months.

Benefits of working in an ITN:

  • You will be working within our international group of > 30 researchers with experience in a broad range of sciences
  • You will get in contact with the other members of this international consortium and will benefit from the joint training platform to develop skills necessary for developing a thorough understanding of the mechanisms of Diabetes and the bone metabolism and for obtaining industry skills.

Your Profile:

  • Applicants must hold a MSc or equivalent in the field of biology, chemistry or a related discipline
  • Applicants must have a solid knowledge of cell and molecular biology as well as biochemistry. Experience with animal experimentation is desired. Willingness to work with animals is a prerequisite
  • Applicants can be of any nationality
  • Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network Training
  • Applicants must be eligible to enroll on a PhD program at the host institution (or a designated university in case the host institution is a non-academic organization)

We offer:

  • You will be employed by the host organization for 36 months.
  • A competitive salary plus allowances. Moreover, funding is available for technical and personal skills training and participation in international research events.
  • You will benefit from the designed training program offered by the host organization and the consortium.
  • You will participate in international conferences and secondments to other organizations within the FIDELIO network and in outreach activities targeted at a wide audience

Please find additional information in the Information package for Marie Curie fellows .

Please quote the reference number MK30919808.We kindly ask you to apply preferably via our online form to make the selection process faster and more effective. Further information on how to apply can be found at our project webpage , too. Of course, we also consider your written application without any disadvantages. Women are explicitly invited to apply. Handicapped persons will be preferred in case of equal qualification. For further information please contact: Prof.Lorenz Hofbauer, Email: Theresa.reiche@ukdd.de

Technische Universität Dresden (TUD) is one of the largest technical universities in Germany and one of the leading and most dynamic institutions in the country. With 18 faculties in five schools, it offers a wide range of degree courses and covers a broad research spectrum with a focus on Health Sciences, Biomedicine & Bioengineering,
Information Technology & Microelectronics, Smart Materials & Structures, Energy, Mobility & Environment as well as Culture & Societal Change, a combination of disciplines which is considered to be exemplary in Germany and throughout Europe. The TUD has about 32,400 students, one seventh of which come from abroad and 8,300 staff hailing from 70 countries. TUD ranks among the Top 100 of Europe’s Most Innovative Universities and in 2012 became one of the German “Universities of Excellence”.

The Bone Lab Dresden , headed by Prof. Dr. Martina Rauner and Prof. Dr. Lorenz Hofbauer is one of the leading facilities in the field of bone research with strong links to national and international partners and an excellent track record in Diabetes & bone, osteoimmunology, osteooncology, osteohematology and matrix biology. We are a
dynamic and enthusiastic team of young researchers striving to unravel the mechanisms underlying osteoporosis, bone metastases and other bone diseases. The state-of-the-art scientific infrastructure at TUD and UKD fosters active scientific networking and dialogue, thereby providing the best conditions for conducting excellent Research.