Benutzerspezifische Werkzeuge

How tumor cells manage oxygen during bone metastasis
09. Oktober 2019

How tumor cells manage oxygen during bone metastasis

by Diana Gaete, Martina Rauner and Ben Wielockx, TU Dresden

And the Nobel Prize for Physiology or Medicine goes to… William Kaelin Jr., Peter Ratcliffe and Gregg Semenza" for their discovery of how cells sense and adapt to oxygen availability."

“This message earlier this week was extremely satisfying as it underlines the importance of our research” says Ben Wielockx, Professor for Inflammatory Disorders at the Institute of Clinical Chemistry and Laboratory Medicine at TU Dresden, who has been unravelling mechanisms of oxygen sensing for the past 10 years. Diana Gaete, PhD student on the project adds “oxygen sensing is such a fundamental process - it affects virtually all physiological and pathophysiological processes including bone physiology and cancer metastasis. As such, it’s a fascinating, but also challenging project to bring it together”. Martina Rauner, Ben’s co-PI, realizes “I am so fortunate to work with Ben and this team. He has such profound knowledge on oxygen sensing. I hope by bringing together our expertise, we can unravel new important mechanisms of oxygen sensing-related bone metastasis”.