Benutzerspezifische Werkzeuge

Summary

In the course of Systemic Inflammatory Response Syndrom (SIRS) there is an increase in vascularisation of the adrenal gland associated with a disruption of the vascular barrier and enhanced leukocyte accumulation in the gland. Leukocyte recruitment requires a series of adhesive interactions between leukocytes and the endothelium. The interaction of endothelial cells and recruited leukocytes with hormone-producing adrenal cells in the inflamed adrenal gland may regulate the endocrine activity of the adrenal gland and the adaptation of the organ to inflammatory stimuli. Nevertheless, the information about the role of leukocyte-endothelial interactions on adrenal dysfunction in inflammation / SIRS is scarce at best. Here, we will study the function of leukocyte-endothelial interactions on adrenal dysfunction in inflammation. A particular emphasis will be laid on the novel endothelial-derived antiadhesive factor, Developmental Endothelial Locus-1 (Del-1), which was recently identified by the group of the applicant. We will engage genetically modified mouse models in order to assess the role of Del-1 on the adrenal function in the course of endotoxemia. We expect that these experiments will improve our understanding of and provide the platform for new therapeutic approaches in the life-threatening adrenal dysfunction in SIRS and sepsis.