Benutzerspezifische Werkzeuge

Project 8

Dissecting the adrenal-endothelial-immune interface in systemic inflammation: Implications for inflammation-related adrenal dysfunction

Maintenance of adrenal function is crucial for the outcome of systemic inflammation. The endogenous inhibitor of leukocyte recruitment Del-1 promotes adrenal homeostasis and counteracts inflammation-related adrenal dysfunction. We are analyzing the effect of cytokines, including IL-17, and of adrenal steroids, such as DHEA in the regulation of the expression and function of Del-1 in adrenal homeostasis.