Benutzerspezifische Werkzeuge

Division of Clinical Neurochemistry

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Division of Clinical Neurochemistry

Chief: Graeme Eisenhofer, PhD

 

The general research conducted within the Division of Clinical Neurochemistry involves preclinical and clinical investigations of neuroendocrine and autonomic nervous systems in health and disease. Expertise in HPLC-ECD and LC-MS/MS assessments of monoamine neurotransmitters and neurohormones represent core strengths of the Division, with applications now extended to steroidomic and energy pathway metabolomics profiling. These methods are being directed to stable-isotope metabolic flux analysis (SIMFA) for in depth investigations of rate processes in model systems. Combined with mathematical modeling, bioinformatics and developing strengths in cell biology, transcriptomics and gene editing these methods together provide a powerful systems biology approach for understanding the pathogenesis and improving the diagnosis and therapy of neuroendocrine tumors and cardiometabolic disorders. The work is undertaken within four closely connected laboratory research units: 1. the Mass Spectrometry unit; 2. the HPLC-ECD/UV unit; 3. the Cell Biology unit; and 4 the Metabolism unit. 

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Links to the clinic are fostered through an additional fifth research unit, the Clinical Studies unit, supported in part by the Department of Medicine III and ensuring access to patients and bi-directional bench-to-bedside and bedside-to-bench components for the research undertaken within the Division. The Clinical Studies unit also represents an integral component of the Adrenal Center Klinische Forschergruppe (KFO252), funded by the Deutsche Forschungsgemeinschaft (DFG), and for which Prof. Eisenhofer acts as the Clinical Research Coordinator. The structure facilitates involvement in multicenter clinical studies and trials, several of which are centered at Dresden and involve collaborators at numerous centers both within and beyond Germany, including multiple European nations, the United States and Australia.

Under the DFG-supported KFO252, a central focus of research for both the Division of Clinical Neurochemistry and other KFO252 research groups involves the adrenal. In addition to adrenal tumors, such as pheochromocytomas, aldosteronomas or cortisol-producing adenomas, this research covers the role of the sympathoadrenal-medullary and cortical systems as central relays controlling bodily functions, coordinating stress responses and contributing to disease processes. Research supported from the European Union and private foundations is also directed at hypertension and cardiovascular disorders, improved diagnostic approaches for neuroblastoma, involvement of mitochondrial energy pathways in cancer, as well as prevention of and new therapies for malignant chromaffin cell tumors.

 
 

Selected Publications

  1. Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014, 99:1915-42.
  2. Eisenhofer G, Lenders JW, Siegert G, Bornstein SR, Friberg P, Milosevic D, Mannelli M, Linehan WM, Adams K, Timmers HJ, Pacak K. Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status. Eur J Cancer. 2012, 48: 1739-49.
  3. Eisenhofer G, Lenders JW, Timmers H, Mannelli M, Grebe SK, Hofbauer LC, Bornstein SR, Tiebel O, Adams K, Bratslavsky G, Linehan WM, Pacak K.Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011, 57:411-20.
  4. Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005, 366:665-75.
  5. Lenders JW1, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, Keiser HR, Goldstein DS, Eisenhofer G. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA. 2002, 287:1427-34.
  6. Eisenhofer G, Lenders JW, Linehan WM, Walther MM, Goldstein DS, Keiser HR. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med. 1999, 340:1872-9.
  7. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, Esler MD. Cardiac sympathetic nerve function in congestive heart failure. Circulation. 1996, 93:1667-76.