Benutzerspezifische Werkzeuge

Clinical Studies Unit

Clinical Studies Unit

Head: Christina Pamporaki, MD, PhD; Jacques W.M. Lenders, MD, PhD (Adjunct Visiting Professor)

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Staff: Mariko Sue, MD, PhD and Christina Skondra, MD (Gerok clinician scientist), Carola Kunath and Katharina Langton (Clinical Research Assistants), An Yaxin (MD student)

The patient-oriented research of the Division is conducted by Clinical Studies unit headed by Dr. Christina Pamporaki. All clinical staff of the unit are closely advised by Professor Jacques Lenders, who visits Dresden one week every month under an adjunct Professorship supported by the Department of Medicine III (Director: Prof Stefan Bornstein). The Clinical Studies unit has also benefited from extended visits of other senior clinicians, including Prof. Michael Bursztyn from Israel whose involvement continues through grant support from the German-Israel Foundation (GIF). In addition to the clinician scientists, supported under rotating DFG-funded Gerok positions (e.g., Dr. Roland Därr) and other mechanisms, the work of the unit is strengthened from the input of two clinical research assistants.

Research of the unit is directed largely towards endocrine hypertension and disordered adrenal function, this based on several local and multi-institutional clinical protocols, including the Dresden-based Prospective Monoamine-producing Tumor (PMT) study (https://pmt-study.pressor.org/jsp/home.jsp). This study, which involves multiple German and European centers, has accrued over 1700 patients as well as over 250 normotensive and hypertensive volunteers for reference purposes. Data are collected into electronic case report forms (eCRFs), with the database maintained by the eResearch Group, headed by Prof. Richard Sinnott at the University of Melbourne, Australia (http://eresearch.unimelb.edu.au). Over 16,000 biospecimens from the study are banked at Dresden, providing a valuable resource for basic research investigators within and outside the Division.

PMT_Clinical_studies

In addition to the PMT study, the unit also contributes to several other international multicenter studies, mainly associated with the European Network for the Study of Adrenal Tumors (ENSAT http://www.ensat.org). Studies include EURINE-ACT, FIRSTMAPPP and the German-based Conn-Registry Diagnostic study and the Cushing registry, among several others. Ongoing local Dresden clinical research protocols include the PRIMMS study (Pediatric Reference Intervals for Monoamine Metabolites and Steroids), the DIAMETs study (Dialysis plasma metanephrines study) and a prospective head and neck paraganglioma tumor study. 

The Clinical Studies unit represents an integral component of the DFG-supported Dresden Adrenal Center, thereby providing a translational link for the many bench-level projects supported within the Klinische Forschergruppe (KFO252). All staff of the unit enjoy close interactions with members of the other four units of the Division. Much of the required laboratory data for clinical studies are provided for by the analytics of the Mass Spectrometry and HPLC-ECD/UV units. The research undertaken within the Cell Biology and Metabolism units similarly benefits from clinical materials, such as tumor specimens and associated patient data, provided for by the staff of the Clinical Studies unit. The unit also provides a resource for training of medical students, further facilitated through an associated MD/PhD program. Students include some who visit on short-term fellowships from outside centers. In fact, the head of the unit, Dr. Pamporaki, initially visited on a five month Erasmus Fellowship before transferring to a Gerok clinician scientist position and from there to head the unit.

Selected Publications

  1. Sue M, Martucci V, Frey F, Lenders J, Timmers HJ, Pęczkowska M, Prejbisz A, Swantje B, Bornstein SR, Arlt W, Fassnacht M, Beuschlein F, Robledo M, Pacak K, Eisenhofer G. Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma. Eur J Endocrinol. 2015 “in press”.
  2. Pamporaki C, Bursztyn M, Reimann M, Ziemssen T, Bornstein SR, Sweep FC, Timmers H, Lenders JW, Eisenhofer G. Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma Eur J Endocrinol. 2014, 170:349-57.
  3. Därr R, Pamporaki C, Peitzsch M, Miehle K, Prejbisz A, Peczkowska M, Weismann D, Beuschlein F, Sinnott R, Bornstein SR, Neumann HP, Januszewicz A, Lenders J, Eisenhofer G. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions. Clin Endocrinol (Oxf). 2014, 80:478-86.
  4. Pamporaki C, Därr R, Bursztyn M, Glöckner S, Bornstein SR, Lenders JW, Pacak K, Krinner A, Eisenhofer G. Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. Clin Endocrinol (Oxf). 2013, 79:476-83.
  5. Därr R, Lenders JW, Hofbauer LC, Naumann B, Bornstein SR, Eisenhofer G. Pheochromocytoma - Update on disease management. Ther Adv Endocrinol Metab. 2012, 3:11-26.