Benutzerspezifische Werkzeuge

Clinical Components

Bedside-to-bench approach: Critical elements of the necessary infrastructure to support acquisition of clinical materials and data for bedside-to-bench studies include an appropriate level of support for the design and implementation of clinical studies, including dedicated space and staffing for patient-oriented research. Clinical materials – including serum, urine, tumour or normal tissue samples – collected into biobanks are of limited utility unless they are also linked to relevant key patient information that allows for appropriate interpretation of the scientific data derived from analyses of those materials at the bench. Thus, the clinical materials for studies at the bench are preferably obtained under institutional ethics committee (IEC) approved clinical protocols supported by a sound rationale and solid scientific objectives to allow for recruitment of human subjects and collection of all relevant medical information.


For research directed at rare disorders, such as those affecting or involving the adrenal glands, multi-institutional studies are usually mandatory to ensure an adequately sized collection of patient materials and data. Consistency of collections is best facilitated by standard operating procedures (SOPs) and a centralized system for electronic collection of patient data, including a linked database inventory outlining availability of procured human materials at participating sites. Z-project based-support of elements critical for patient-oriented research, as covered below, ensures that the appropriate infrastructure is in place for the bedside-to-bench research outlined in individual projects. More importantly for the future, this infrastructure provides the necessary support at the clinic that, together with infrastructure outlined below for mouse models, will ensure success of future bench-to-bedside initiatives arising from those projects.