Benutzerspezifische Werkzeuge

Basic Components

Bench-to-bedside approach: Aside from the Z-project-based support of the bedside-to-bench approach as mentioned above, the Z-project will strengthen the infrastructure for translational studies. For this purpose, the establishment and maintenance of a facility supporting a bank of preclinical mouse models of disease is essential. Genetically modified mouse models, which enable gene deletion in almost each single cellular component of the adrenal gland, will allow for a detailed dissection of the physiology and pathophysiology of the adrenal gland microenvironment. In addition, these models will serve for identifying and testing novel therapeutic targets and therapies to enable the bridging of basic findings to the clinic.

As outlined earlier, both bedside-to-bench and bench-to-bedside approaches will largely involve and profit from support of physician-scientist Gerok positions. For instance, a physician-scientist on a Gerok position involved in projects #7 and #8 will help translate the basic knowledge generated in these projects regarding the role of inflammation in adrenal dysregulation in sepsis into novel clinical diagnostic tools for septic patients. Additionally, Gerok physicians will assist in the translation of the islet cell transplantation into the adrenal. In addition, clinician-scientists on the Gerok position will facilitate transfer of data and results from clinical studies (e.g. generated in projects #2, #5 or #6) back to the bench.