Benutzerspezifische Werkzeuge

Evidence/based Healthcare

Clinical trials and routine health-care data for an optimal treatment.

Clinical care should be based on appropriate evidence, obtained from large clinical trials. Therefore, the SC-FNH aims to include patients in clinical trials, in order to improve management. Furthermore, routine data for children in Saxony are used to analyse the current situation and to define need for future research.

The SC-FNH is  part of a large collaborative network for clinical trials (together with CPCS, Tübingen), the German Neonatal Network and the Forschungsnetzwerk der DGPM.

The different projects have been funded in the past by Bundesministerium für Bildung und Forschung (BMBF), Bundesministerium für Gesundheit (BMG), AOK Bundesverband. Current projects are funded by European Union (Horizon 2020).

Currently, clinicians and scientists work on the following studies:

  • Clinical Studies in extremely preterm infants (Dr. Barbara Seipolt)
  • Analysis of Health Care Data (Prof. Dr. Jochen Schmitt)
  • Register for Covid-19 in pregnancy (Dr. Lars Mense)
  • ALBINO-trial (Dr. Stefan Winkler)
  • Crystal consumtion during pregnancy (PD. Dr. Jürgen Dinger)
  • Treatment of the Patent Ductus arteriosus (Prof. Dr. Sigrun Hofmann)
  • Improving nutrition of preterm infants (Dr. Katrin Weber)

Collaborations

Center for Pediatric Clinical Studies, Universität Tübingen (CPCS);

AOK Plus;

AOK Bundesverband;

Forschungsnetzwerk Deutsche Gesellschaft für Perinatale Medizin (DGPM)

Publications

CRONOS-Netzwerk: Pregnancy and SARS CoV-2 infection in Germany - the CRONOS registry. Pecks U, Kuschel B, Mense L, Oppelt P, Rüdiger M. Dtsch Arztebl Int 2020; 117: 841-2. DOI:10.3238/arztebl.2020.0841

Impact of regionalisation and case-volume on neonatal and perinatal mortality: an umbrella review. Walther F, Küster DB, Bieber A, Rüdiger M, Malzahn J, Schmitt J, Deckert S. BMJ Open. 2020 Sep 25;10(9):e037135. doi: 10.1136/bmjopen-2020-037135

Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial. Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators. JAMA. 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690

Neonatal and young infant sepsis by Group B Streptococci and Escherichia coli: a single-center retrospective analysis in Germany-GBS screening implementation gaps and reduction in antiobiotic reistance. Doenhardt M, Seipolt B, Mense L, Winkler JL, Thürmer A, Rüdiger M, Berner R, Armann J. Eur J Pediatr. 2020 Nov;179(11):1769-1777. doi: 10.1007/s00431-020-03659-8. Epub 2020 May 23

Individual-Level Linkage of Primary and Secondary Data from Three Sources for Comprehensive Analyses of Low Birthweight Effects. Druschke D, Arnold K, Heinrich L, Reichert J, Rüdiger M, Schmitt J. Gesundheitswesen. 2020 Mar;82(S 02):S108-S116. doi: 10.1055/a-1082-0740. Epub 2020 Mar 19

Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age. Humberg A, Spiegler J, Fortmann MI, Zemlin M, Marissen J, Swoboda I, Rausch TK, Herting E, Göpel W, Härtel C; German Neonatal Network (GNN). Sci Rep. 2020 Feb 11;10(1):2373. doi: 10.1038/s41598-020-58761-6

Hospital survey showed wide variations in therapeutic hypothermia for neonates in Germany. Giannakis S, Ruhfus M, Rüdiger M, Sabir H; German Neonatal Hypothermia Network. Acta Paediatr. 2020 Jan;109(1):200-201. doi: 10.1111/apa.14979. Epub 2019 Sep 30

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo.conrolled parallel group multicenter trial for superiority (phase III). Maiwald CA, Annink KV, Rüdiger M, Benders MJNL, van Bel F, Allegaert K, Naulaers G, Bassler D, Klebermaß-Schrehof K, Vento M, Guimarães H, Stiris T, Cattarossi L, Metsäranta M, Vanhatalo S, Mazela J, Metsvaht T, Jacobs Y, Franz AR; ALBINO Study Group. BMC Pediatr. 2019 Jun 27;19(1):210. doi: 10.1186/s12887-019-1566-8

Impact of birthweight on health-care utilization during early childhood - a birth cohort study. Rüdiger M, Heinrich L, Arnold K, Druschke D, Reichert J, Schmitt J. BMC Pediatr. 2019 Mar 1;19(1):69. doi: 10.1186/s12887-019-1424-8

Sniffin' Away the Feeding Tube: The Influence of Olfactory Stimulation on Oral Food Ontake in Newborns and Premature Infants. Schriever VA, Gellrich J, Rochor N, Croy I, Cao-Van H, Rüdiger M, Hummel T. Chem Senses. 2018 Aug 24;43(7):469-474. doi: 10.1093/chemse/bjy034

Development of a Diagnostic Clinical Score for Hemodynamically Significant Patent Ductus Arteriosus. Kindler A, Seipolt B, Heilmann A, Range U, Rüdiger M, Hofmann SR. Front Pediatr. 2017 Dec 22;5:280. doi: 10.3389/fped.2017.00280. eCollection 2017

Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia? Spiegler J, Preuß M, Gebauer C, Bendiks M, Herting E, Göpel W; German Neonatal Network (GNN); German Neonatal Network GNN. J Pediatr. 2016 Feb;169:76-80.e4. doi: 10.1016/j.jpeds.2015.10.080. Epub 2015 Nov 25