GlioMath-DD

Short Description

The GlioMath-Dresden project is a cooperation of six interdisciplinary institute groups of the Universitätsklinikum Dresden and The Technische Universität Dresden to study for a better understanding of evolution from glioma to get new impulses for patient-specific therapies.

Within the work secondary glioblastoma and corresponding precursor tumours are analysed using modern molecular high-throughput sequencing of the transcriptome such as array comparative genome hybridization (aCGH), Exome-Seq, RNA-Seq and miRNA microarrays. In addition, we will characterize in vitro primary cell cultures obtained from patients. Ultimately, this work will elucidate the progression of this serious cancer and help to identify molecular targets for therapy. Furthermore, the data generated will be used to build a mathematical model of glioma that will further help to understand the fundamentals of glioma promotion and progression.

Coordinator of the project

Prof. Dr. Andreas Deutsch
Center for Information Services and High Performance Computing (ZIH)

Cooperating partners

Dr. Andreas Beyer
TU Dresden, Institute of Biotechnology (BIOTEC)

PD Dr. Kathrin Geiger
University Hospital Carl Gustav Carus Dresden, Institute of Pathology

Prof. Dr. Leoni Kunz-Schughart
TU Dresden, OncoRay- National Center of Radiation Research in Oncology

Prof. Dr. Wolfgang E. Nagel
TU Dresden, Center for Information Services and High Performance Computing (ZIH)

Prof. Dr. Evelin Schröck
Medical Faculty Dresden, Institute for Clinical Genetics

Prof. Dr. Hanns Achim Temme
TU Dresden, Department of Neurosurgery, NCH-FOR

Funding

The Glio-Math-Dresden project is supported by European Social Fund and the Free State of Saxony.

Funding period

08/2012-12/2014