Benutzerspezifische Werkzeuge

Research Focus

Our project group investigates new prognostic factors in renal and bladder cancer using DNA, RNA and tissue arrays. Here, we are collaborating with the Department of Urology, Technical University Dresden. Additionally, we are members of the international “renal cell carcinoma network” which consists of specialists from Germany and Switzerland and the national “bladder carcinoma network”.

Research Findings

Using single nucleotide polymorphism arrays (SNP arrays) we previously screened DNA isolated from clear cell renal cell carcinomas and found new small deletions and loss of heterozygosity (LOH) (Toma et al., 2008).  Now, we are confirming the data in a large patient cohort with known clinical data and follow-up. We are interested in the methylation status, DNA copy number changes and RNA and protein status of several genes located on chromosomes 1, 3, 5 and 6.