Benutzerspezifische Werkzeuge

Research groups - Dalpke lab

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Prof. Dr. med. Alexander Dalpke

Institute of Medical Microbiology and Hygiene

0351 458-6550


The focus of my research is infection and immunity. Recent work centers on three topics:

1. We are studying the recognition of microbial nucleic acids by pattern recognition receptors. We try to elucidate principles that enable Toll-like receptors to differentiate foreign, microbial from self nucleic acids. Specifically, we address the importance of RNA modifications and RNA degradation on immune stimulation.

2. With the ongoing COVID19 pandemics we started projects on activation of airway epithelial cells and innate immune cells by SARS-CoV2. Furthermore we engage in a project that elucidates virus distribution across borders by virus genome sequencing and phylogenetic analysis.

3. A recent project area studies polymicrobial infections by means of next generation sequencing. We focus on patients suffering from cystic fibrosis (CF) but also use the technique to explore microbiome changes in other diseases. In CF we aim to analyze microbiome alterations in early childhood as well as during exacerbation and focus on interactions of commensal and pathogenic bacteria.

Projects

1. Innate Immunity  

2 SARS-CoV2 

    

 3. CF microbiome  

 


Publications

Funding: DFG Da592-7, DFG Da592-10, DFG Da592-12, DFG TRR319-A03, Mukoviszidose e.V., GILEAD, Becton Dickinson