Benutzerspezifische Werkzeuge

Projekt 2

Projekt 2

SARS CoV2              

                                           

During the ongoing pandemic we started to work on basic science as well as epidemiological questions regarding infection biology of SARS-CoV2. In one project we address early immunostimulation upon infection of airway epithelial cells or blood immune cells with the virus. We want to analyze how the virus is sensed and why in some cases inappropriate immune responses, associated with more severe courses, develop. In epidemiological projects we study infections in childcare and school environment. Moreover, we run a sequencing project that analyzes phylogeny and distribution of SARS-CoV2 with a focus on the Saxony and that especially concentrates on German-Czech-Poland cross border distribution. Work is accompanied by a surveillance project in wastewater. Data are reported to political decision makers. Further work is on development of rapid and easy detection assays using nucleic acid amplification together with partners from the Technical University.

 

Selected publications

Yi B, Poetsch A, Stadtmüller M, Rost F, Winkler S, Dalpke A (2021). Phylogenetic analysis of SARS-CoV-2 lineage development across the first and second waves in Eastern Germany in 2020: Insights into the cause of the second wave. Epidemiology and Infection, 149: e177

Kirsten C, Unrath M, Lück C, Dalpke AH, Berner R, Armann JP (2021): SARS-CoV-2 seroprevalence in students and teachers – a longitudinal study from May to October 2020 in German secondary schools. BMJ Open 11(6):e049876

Galow L, Haag L, Kahre E, Blankenburg J, Dalpke AH, Lück C, Berner R, Armann JP (2021): Lower household transmission rates of SARS-CoV-2 from children compared to adults. J Infect, 83(1):e34-e36

Armann JP, Kirsten C, Galow L, Kahre E, Haag L, Dalpke AH, Lück C, Berner R (2021): SARS-CoV-2 transmissions in students and teachers – seroprevalence follow-up study in a German secondary school in November and December 2020. BMJ Paediatrics Open, 5(1):e001036.

Dumke R, de la Cruz Barron M, Oertel R, Helm B, Kallies R, Berendonk TU, Dalpke A (2021): Evaluation of two methods to concentrate SARS-CoV-2 from untreated wastewater. Pathogens, 10(2): 195